40545-76-4

Basic information

• Product Name: Benzenamine, 4-chloro-2-(phenylmethyl)-
• CAS NO: 40545-76-4
• Molecular Formula: C13H12ClN
• Molecular Weight: 217.698
• Mol File: 40545-76-4.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzenamine, 4-chloro-2-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenamine, 4-chloro-2-(phenylmethyl)-(40545-76-4)
• EPA Substance Registry System: Benzenamine, 4-chloro-2-(phenylmethyl)-(40545-76-4)

Safety Data

• Hazardous Substances Data: 40545-76-4(Hazardous Substances Data)

Upstream product

• 28059-64-5 2-benzylaniline 
• 7039-53-4 2-amino-5-chlorobenzophenone hydrazone 
• 1159372-20-9 (2-amino-5-chlorophenyl)(phenyl)methanol 
• 719-59-5 5-chloro-2-aminobenzophenone 
• 67862-89-9 7-Chlor-3-methyl-5-phenyl-2-thioxo-3H-1,2-dihydro-1,3,4-benzotriazepins 
• 2855-58-5 7-Chlor-2-oxo-5-phenyl-1H-2,3-dihydro-1,3,4-benzotriazepin 
• 53002-25-8 7-Chlor-3-methyl-2-oxo-5-phenyl-1,2-dihydro-3H-1,3,4-benzotriazepin 
• 73549-45-8 7-Chlor-5-phenyl-2-thioxo-1H-2,3-dihydro-1,3,4-benzotriazepin 

Downstream Products

• 59639-25-7 5-chloro-2-imidazol-1-yl-benzophenone 
• 59639-21-3 1-(4-chloro-α-phenyl-o-tolyl)imidazole 
• 54534-20-2 5-chloro-2-(2-dimethylaminomethyl-imidazol-1-yl)-benzophenone 
• 59678-87-4 5-chloro-2-(2-hydroxymethylimidazol-1-yl)benzophenone 
• 121899-01-2 7-chloro-9-<2-(dimethylamino)ethoxyl>-9-phenyl-9H-imidazo<1,2-a>indole 
• 121898-98-4 7-Chloro-3-dimethylaminomethyl-9-phenyl-9H-imidazo[1,2-a]indol-9-ol 
• 121898-97-3 7-Chloro-9-phenyl-9H-imidazo[1,2-a]indol-9-ol 
• 61875-59-0 N-(2-Benzyl-4-chloro-phenyl)-formimidic acid ethyl ester 
• 859793-81-0 (2-benzyl-4-chloro-phenyl)-arsonic acid 

Relevant articles and documents

Recyclable ionic liquid iodinating reagent for solvent free, regioselective iodination of activated aromatic and heteroaromatic amines

This article describes a simple, efficient method for iodination of activated aromatic and heteroaromatic amines using recyclable 1-butyl-3-methylpyridinium dichloroiodate (BMPDCI) as an ionic liquid iodinating reagent, in the absence of any solvent. The main advantages are a simple efficient procedure, good yields and no need for any base/toxic heavy metals, or oxidizing agents. The ionic liquid was recovered and recycled in five subsequent reactions, without much loss of activity. This method was applied for the synthesis of the antiprotozoal drug iodoquinol and the antifungal drug clioquinol.

The studies of the intramolecular C-F---H-N hydrogen bonding using covalently-linked base pair models of F and A

Both 1H NMR and X-ray studies revealed that C-F---H-N intramolecular hydrogen bonding is not observed even in covalently-linked base pair models of F and A. These results strongly support the Kool's hypothesis.

2-(Imidazol-1-yl)benzophenones

Compounds of the formulae IV and V: SPC1 wherein Ro and R1 are hydrogen or alkyl of 1 to 3 carbon atoms, inclusive; wherein R2 is hydrogen, fluoro, chloro, or trifluoromethyl; wherein R3 is hydrogen or fluoro with the proviso that R3 cannot be fluoro, if R2 is chloro or trifluoromethyl; and wherein R4 is hydrogen, fluoro, chloro, bromo, trifluoromethyl, or nitro, are obtained by a multi-step reaction from the corresponding α-(phenyl)-o-toluidine of the formula I SPC2 wherein R2, R3, and R4 are defined as above, by treating I in sequence with an alkyl ester of orthoformic acid the resulting product with 2-alkyl-2-(aminoalkyl)-1,3-dioxolane or a 2-amino-alkanone dialkyl ketal and finally with titanium tetrachloride to obtain compound IV, and oxidizing compound IV to obtain the corresponding compound V. Compounds IV and V have minor tranquilizing activity which can be utilized to calm mammals or birds. Their more important use, however, is as intermediates in the production of the strongly sedating and tranquilizing imidazolobenzodiazepines.