40557-20-8

Basic information

• Product Name: 3-bromopyrrolidin-2-one
• Synonyms: 3-bromopyrrolidin-2-one;3-broMo-2-Pyrrolidinone;2-Pyrrolidinone, 3-broMo-;3-BroMo-2-pyrrolidone;alpha-Bromobutyrolactam
• CAS NO: 40557-20-8
• Molecular Formula: C₄H₆BrNO
• Molecular Weight: 164.00054
• Mol File: 40557-20-8.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 305.787 °C at 760 mmHg
• Flash Point: 138.735 °C
• Appearance: /
• Density: 1.715 g/cm³
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• CAS DataBase Reference: 3-bromopyrrolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-bromopyrrolidin-2-one(40557-20-8)
• EPA Substance Registry System: 3-bromopyrrolidin-2-one(40557-20-8)

Safety Data

• Hazardous Substances Data: 40557-20-8(Hazardous Substances Data)

Usage

General Description

3-bromopyrrolidin-2-one is a chemical compound with the molecular formula C4H6BrNO. It is a white solid that is soluble in water and has a melting point of 53-55°C. 3-bromopyrrolidin-2-one is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. It is also used as an intermediate in the production of various organic compounds. 3-bromopyrrolidin-2-one has a versatile reactivity and can participate in a variety of chemical reactions, making it a valuable tool for chemists in the development of new compounds and materials. It is important to handle this compound with care, as it may pose health and environmental risks if not used properly.

Upstream product

• 3130-75-4 4-phthalimidobutyric acid 
• 59882-37-0 2,4-dibromobutyramide 

Downstream Products

• 214286-31-4 1-acetyl-3-bromo-pyrrolidin-2-one 
• 136203-01-5 3-[4-(3,5-Di-tert.-butyl-4-hydroxyphenyl)thiazol-2-yl methylidene]pyrrolidin-2-one 
• 42491-95-2 3-acetoxy-2-pyrrolidinone 

Relevant articles and documents

PRODUCTION METHOD OF HETEROCYCLIC MERCAPTO COMPOUND

A method of the invention industrially produces heterocyclic mercapto compounds useful as raw materials or intermediates in the synthesis of medicaments or pesticides, or as permanent wave agent, with a high yield and high productivity using easily available starting materials. A heterocyclic mercapto compound represented by Formula (1) (wherein X represents any structure of -O-, -S-, -NH-, and -NR1-; R1 represents any of an alkyl group, alkoxy group and alkoxyalkyl group each having 1 to 6 carbon atoms; Y represents an oxygen atom, a sulfur atom or -NR2-; R2represents a hydrogen atom or alkyl group having 1 to 6 carbon atoms; and Z1 represents a divalent organic residue having at least one mercapto group) is produced by reacting a metal sulfide or a metal hydrosulfide with a compound represented by Formula (2) (wherein X and Y are as defined in Formula (1); and Z2 represents a divalent organic residue having at least one halogen group) in the presence of a solvent at a pH of 7.0 to 11.0.

THIAZOL-COMPOUNDS AS 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS

The present invention relates to compounds with the formula (I), wherein R1, R2, R3, X, and Y are as defined herein, and also to pharmaceutical compositions comprising the compounds, as well as to the use of the compounds in medicine and for the preparation of a medicament which acts on the human 11-β-hydroxysteroid dehydrogenase type 1 enzyme.

Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis

Peptido and peptidomimetic compounds of the formula: wherein the formula variables are as defined in the disclosure, advantageously inhibit or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compos