40567-18-8

Basic information

• Product Name: 1-(2,4,6-Trichlorophenyl)-3-(3-aminobenzamido)-5-pyrazolone
• Synonyms: 3-amino-n-[4,5-dihydro-5-oxo-1-(2,4,6-trichlorophenyl)-1h-pyrazol-3-benzamid;1-(2,4,6-trichlorophenyl)-3-(3-aminobenzamido)-5-pyrazolone;1-(2,4,6-Trichlorophenyl)-3-(3-aminobenzoyl)amino-2-pyrazolin-5-one;3-AMINO-N-[5-OXO-1-(2,4,6-TRICHLOROPHENYL)-1H-PYRAZOLIN-3-YL]BENZAMIDE;3-Amino-N-[4,5-dihydro-5-oxo-1-(2,4,6-trichlorophenyl)-1H-pyrazol-3-yl]-benzamide;1-(2,4,6-Trichlorophenyl)-3-(M-Aminobenzamido)-5-Pyrazolone;3-amino-N-[4,5-dihydro-5-oxo-1-(2,4,6-trichlorophenyl)-1H-pyrazol-3-yl]-Benzamide 3-amino-n-[4,5-dihydro-5-oxo-1-(2,4,6-trichlorophenyl)-1h-pyrazol-3-benzamid;1-(2,4,6-Trichlorophenyl)-3-(3-aminobenzoylamino)-5(4H)-pyrazolone
• CAS NO: 40567-18-8
• Molecular Formula: C₁₆H₁₁Cl₃N₄O₂
• Molecular Weight: 397.64
• EINECS: 254-979-6
• Mol File: 40567-18-8.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Density: 1.62 g/cm³
• Refractive Index: 1.735
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-(2,4,6-Trichlorophenyl)-3-(3-aminobenzamido)-5-pyrazolone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,4,6-Trichlorophenyl)-3-(3-aminobenzamido)-5-pyrazolone(40567-18-8)
• EPA Substance Registry System: 1-(2,4,6-Trichlorophenyl)-3-(3-aminobenzamido)-5-pyrazolone(40567-18-8)

Safety Data

• Hazardous Substances Data: 40567-18-8(Hazardous Substances Data)

Usage

General Description

1-(2,4,6-Trichlorophenyl)-3-(3-aminobenzamido)-5-pyrazolone, also known as TAP, is a synthetic chemical compound that falls under the category of pyrazolone derivatives. It is a crystalline, yellow-colored powder that is commonly used in the pharmaceutical industry as an intermediate in the manufacturing of various medications, particularly nonsteroidal anti-inflammatory drugs (NSAIDs) and analgesics. TAP possesses both anti-inflammatory and analgesic properties, making it a valuable component in the development of new pharmaceutical products. Additionally, TAP has been studied for its potential anti-cancer and anti-fungal activities, further expanding its potential applications beyond traditional pain relief and inflammation treatment. Overall, TAP is a versatile and important chemical compound with diverse uses and potential therapeutic benefits.

InChI:InChI=1/C16H11Cl3N4O2/c17-9-5-11(18)15(12(19)6-9)23-14(24)7-13(22-23)21-16(25)8-2-1-3-10(20)4-8/h1-7,22H,20H2,(H,21,25)

Upstream product

• 121-90-4 m-nitrobenzoic acid chloride 
• 27241-31-2 3-amino-1-(2',4',6'-trichlorophenyl)-4,5-dihydropyrazol-5(1H)-one 
• 63134-25-8 3-(3''-nitrobenzoylamino)-1-(2',4',6'-trichlorophenyl)-4,5-dihydropyrazol-5(1H)-one 

Downstream Products

• 31188-91-7 3-[3-(2'',4''-di-tert-pentyl)phenoxyacetamido]benzoylamino-1-(2',4',6'-trichlorophenyl)-4,5-dihydropyrazol-5(1H)-one 

Relevant articles and documents

Synthesis of 3-(3″-aminobenzoylamido)-1-(2′,4′,6′- trichlorophenyl)pyrazol-5-one, an intermediate in the synthesis of the purple component of color photographic materials

Catalytic reduction of 3-(3″-nitrobenzoylamido)-1-(2′,4′, 6′-trichlorophenyl)pyrazol-5-one with hydrogen and hydrazine hydrate to 3-(3″-aminobenzoylamido)-1-(2′,4′,6′-trichlorophenyl) pyrazol-5-one, the key intermediate in the synthesis of the purple component of color photographic and motion-picture materials, was studied.