405911-17-3

Basic information

• Product Name: GW 3965 HYDROCHLORIDE
• Synonyms: 3-[3-[n-(2-chloro-3-trifluoromethylbenzyl)-(2,2-diphenylethyl)amino]propyloxy]phenylacetic acid hydrochloride;3-[3-[n-(2-chloro-3-trifluoroMethylbenzyl)-(2,2-di…;GW3965 HCl;2-[3-[3-[[2-Chloro-3-(trifluoromethyl)benzyl](2,2-diphenylethyl)amino]propoxy]phenyl]acetic acid hydrochloride;GW3965 hydrochloride, >=98%;Benzeneacetic acid, 3-[3-[[[2-chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino]propoxy]-, hydrochloride;GW3965 HCl Salt
• CAS NO: 405911-17-3
• Molecular Formula: C33H31ClF3NO3.HCl
• Molecular Weight: 618.51300
• Product Categories: Inhibitors
• Mol File: 405911-17-3.mol
• Article Data: 0

Chemical Properties

• Appearance: white/
• Solubility: DMSO: ≥20mg/mL
• CAS DataBase Reference: GW 3965 HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: GW 3965 HYDROCHLORIDE(405911-17-3)
• EPA Substance Registry System: GW 3965 HYDROCHLORIDE(405911-17-3)

Safety Data

• Hazard Codes: Xn
• Statements: 22-41
• Safety Statements: 26-39
• WGK Germany: 3
• Hazardous Substances Data: 405911-17-3(Hazardous Substances Data)

Usage

Description

GW 3965 HYDROCHLORIDE is a potent and selective liver X receptor (LXR) agonist specifically targeting human LXRα and LXRβ. It is known for its significant anti-inflammatory properties, making it a valuable compound in the field of pharmaceuticals and healthcare.

Uses

Used in Pharmaceutical Industry:
GW 3965 HYDROCHLORIDE is used as an anti-inflammatory agent for its potent activity in reducing inflammation in both irritant and allergic contact models of dermatitis. This application is particularly relevant due to the involvement of both LXRα and LXRβ in its mechanism of action.
Used in Dermatology:
In the field of dermatology, GW 3965 HYDROCHLORIDE is utilized as a therapeutic agent for treating various skin conditions characterized by inflammation, such as dermatitis. Its ability to target both LXRα and LXRβ makes it a promising candidate for managing skin inflammation effectively.

Biochem/physiol Actions

GW3965 is a liver X receptor full agonist on hLXRα and hLXRβ. GW3965 has an EC50 = 125 nM in a cell-free ligand-sensing assay of LXRα and profiles as a full agonist on hLXRα and hLXRβ in cell-based assays with EC50 = 190 nM and 30 nM, respectively. It is orally active in mice. When screened against a panel of nuclear receptors, it cross-reacted with only the pregnane X receptor (PXR). The literature agonist, T0901317 (Tularik), had an EC50 = 60 nM and 85 nM in the cell-free and cell-based assays, respectively.