40610-41-1

Basic information

• Product Name: IMp. K (EP)
• Synonyms: IMp. K (EP);AMpicillin EP IMpurity K;AMpicillin iMpurity K
• CAS NO: 40610-41-1
• Molecular Formula: C₁₃H₁₇NO₃
• Molecular Weight: 235.29
• Mol File: 40610-41-1.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 441.5±38.0 °C(Predicted)
• Appearance: /
• Density: 1.141±0.06 g/cm3(Predicted)
• PKA: 3.28±0.10(Predicted)
• CAS DataBase Reference: IMp. K (EP)(CAS DataBase Reference)
• NIST Chemistry Reference: IMp. K (EP)(40610-41-1)
• EPA Substance Registry System: IMp. K (EP)(40610-41-1)

Safety Data

• Hazardous Substances Data: 40610-41-1(Hazardous Substances Data)

Usage

Description

IMp. K (EP), also known as (R)-2-Phenyl-2-pivalamidoacetic Acid, is an impurity found in Ampicillin, a β-lactam antibiotic used for treating bacterial infections. Ampicillin works by interfering with the cell wall synthesis in bacteria, making it an essential component in the fight against bacterial infections.

Uses

Used in Pharmaceutical Industry:
IMp. K (EP) is used as an impurity in the production of Ampicillin (A634300) for the following reasons:
1. As a β-lactam antibiotic, Ampicillin is effective in treating a wide range of bacterial infections, making it a crucial component in the pharmaceutical industry.
2. The presence of IMp. K (EP) as an impurity in Ampicillin may affect the drug's efficacy, safety, and quality. Therefore, it is essential to monitor and control the levels of this impurity during the manufacturing process to ensure the drug meets the required standards.

Upstream product

• 100-42-5 styrene 
• 60050-53-5 2-phenyl-2-pivalamidoacetic acid 
• 292638-85-8 acrylic acid methyl ester 
• 3282-30-2 pivaloyl chloride 
• 2835-06-5 phenylglycin 
• 875-74-1 (R)-phenylglycine 

Downstream Products

• 1420293-77-1 C₁₃H₁₆NO₃^(1-)*C₁₆H₃₆N⁽¹⁺⁾ 

Relevant articles and documents

Enantioselective C-H Olefination of α-Hydroxy and α-Amino Phenylacetic Acids by Kinetic Resolution

Significant progress has been made in the past decade regarding the development of enantioselective C-H activation reactions by desymmetrization. However, the requirement for the presence of two chemically identical prochiral C-H bonds represents an inherent limitation in scope. Reported is the first example of kinetic resolution by a palladium(II)-catalyzed enantioselective C-H activation and C-C bond formation, thus significantly expanding the scope of enantioselective C-H activation reactions.