406192-82-3

Basic information

• Product Name: 1H-Indole-5-carboxylicacid,hydrazide(9CI)
• Synonyms: 1H-Indole-5-carboxylicacid,hydrazide(9CI);1H-Indole-5-carbohydrazide;1H-Indole-5-carboxylic acid, hydrazide
• CAS NO: 406192-82-3
• Molecular Formula: C9H9N3O
• Molecular Weight: 175.19
• Product Categories: CYCLOHEXANE
• Mol File: 406192-82-3.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• Density: 1.353±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• PKA: 12.90±0.30(Predicted)
• CAS DataBase Reference: 1H-Indole-5-carboxylicacid,hydrazide(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole-5-carboxylicacid,hydrazide(9CI)(406192-82-3)
• EPA Substance Registry System: 1H-Indole-5-carboxylicacid,hydrazide(9CI)(406192-82-3)

Safety Data

• Hazardous Substances Data: 406192-82-3(Hazardous Substances Data)

Usage

General Description

1H-Indole-5-carboxylic acid hydrazide (9CI) is a chemical compound that falls under the category of indoles, which are organic compounds containing a benzene ring fused to a pyrrole ring. The presence of carbonylic acid hydrazide gives this chemical additional reactivity, which can be utilized in the formation of more complex structures. Attributes such as these make it beneficial to various chemical and pharmaceutical research. However, specific details or data regarding its physical properties or real-world applications are hard to find, implying it might not be extensively studied. Like all chemicals, careful handling is necessary to prevent adverse effects.

Upstream product

• 32996-16-0 ethyl indole-5-carboxylate 
• 1011-65-0 5-methoxycarbonylindole 
• 1670-81-1 1H-Indole-5-carboxylic acid 

Downstream Products

• 1256634-22-6 (1H-indol-5-yl)(3-(4-methoxyphenyl)-5-p-tolyl-4,5-dihydropyrazol-1-yl)methanone 

Relevant articles and documents

INHIBITORS OF HEPATITIS C VIRUS REPLICATION

The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.

A double-indole hydrazone compound and use thereof

The invention provides a bisindole acylhydrazone compound shown as the formula I or salt, hydrate or crystals, accepted in the pharmacy, of the bisindole acylhydrazone compound. According to the bisindole acylhydrazone compound, R does not exist or is selected from alkylene of C1-5. The bisindole acylhydrazone compound has a certain antibacterial activity, and can serve as potential antibiotics or a daily chemical product. What is beyond the expectation is that compounds 4e-4h and compounds 4a-4c are quite similar in structure, the antibacterial activity of the compounds 4e-4h and the antibacterial activity of the compounds 4a-4c are obviously better than that of other compounds, particularly, the activity of the compound 4h is best and is remarkably better than that of compounds 4e-4g. The formula I is shown in the specification.

A antibacterial synthetic method of the compound

The invention provides a synthesis method of a bisindolyl acylhydrazone compound represented by a formula I shown in specifications, wherein acyl is connected with a carbon atom of a 4-, 5- or 6-bit of indolyl. The synthesis method provided by the invention has the advantages of high speed, high efficiency, low solvent consumption and relatively high target compound yield, thereby providing a necessary basis for further researching the compound represented by the formula I or related compounds. An intermediate provided by the invention is simple in structure and is easy to obtain, so that convenience is provided for the preparation of target compounds.