406218-17-5

Basic information

• Product Name: (R)-4-hydroxy-4-phenylbutyramide
• Synonyms: (R)-4-hydroxy-4-phenylbutyramide
• CAS NO: 406218-17-5
• Molecular Weight: 179.219
• Mol File: 406218-17-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (R)-4-hydroxy-4-phenylbutyramide(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-4-hydroxy-4-phenylbutyramide(406218-17-5)
• EPA Substance Registry System: (R)-4-hydroxy-4-phenylbutyramide(406218-17-5)

Safety Data

• Hazardous Substances Data: 406218-17-5(Hazardous Substances Data)

Upstream product

• 111138-03-5 (R)-4-phenylbutyrolactone 
• 25333-24-8 3-benzoylpropionic acid methyl ester 
• 99512-38-6 (R)-methyl 4-hydroxy-4-phenylbutanoate 
• 23132-29-8 4-oxo-4-phenylbutanamide 

Downstream Products

• 406218-18-6 (R)-6-phenyl-1,3-oxazinan-2-one R-7a 

Relevant articles and documents

A practical asymmetric synthesis of (R)-fluoxetine and its major metabolite (R)-norfluoxetine

A convenient and chromatography-free synthesis for the enantiomers of fluoxetine and norfluoxetine is described. The synthesis relied on the use of the CBS reduction, and Hofman rearrangement to establish the key common intermediate 5, and enrichment of optical purity of the final product by crystallization as the tartrate salt.

Methods of using norfluoxetine

The invention encompasses methods of using racemic and enantiomerically pure norfluoxetine, as well as pharmaceutical compositions, pharmaceutical unit dosage forms, and kits comprising racemic and enantiomerically pure norfluoxetine. In particular, the i