406235-30-1

Basic information

• Product Name: N-BOC-4-METHYL-4-HYDROXY PIPERIDINE
• Synonyms: N-BOC-4-METHYL-4-HYDROXY PIPERIDINE;1-BOC-4-METHYL-PIPERIDIN-4-OL;4-HYDROXY-4-METHYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;1-Boc-4-hydroxy-4-methylpiperidine;1-boc-4-methyl-piperidine-4-ol;1-Piperidinecarboxylicacid,4-hydroxy-4-Methyl-,1,1-diMethylethylester;4-Hydroxy-4-methylpiperidine-1-carboxylic acid tert-butyl estercarboxylate;EOS-61414
• CAS NO: 406235-30-1
• Molecular Formula: C₁₁H₂₁NO₃
• Molecular Weight: 215.29
• Mol File: 406235-30-1.mol
• Article Data: 35

Chemical Properties

• Boiling Point: 296.362 °C at 760 mmHg
• Flash Point: 133.035 °C
• Appearance: /
• Density: 1.076 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.488
• Storage Temp.: 2-8°C
• CAS DataBase Reference: N-BOC-4-METHYL-4-HYDROXY PIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-BOC-4-METHYL-4-HYDROXY PIPERIDINE(406235-30-1)
• EPA Substance Registry System: N-BOC-4-METHYL-4-HYDROXY PIPERIDINE(406235-30-1)

Safety Data

• Hazardous Substances Data: 406235-30-1(Hazardous Substances Data)

Usage

General Description

N-BOC-4-Methyl-4-Hydroxy Piperidine is a synthetic organic compound that belongs to the class of chemical entities known as piperidines. Piperidines are compounds containing a piperidine ring, which is a saturated heterocycle made up of one nitrogen atom and five carbon atoms. The 'N-BOC' part of the name refers to a common protecting group used in organic synthesis. They shield amine groups from unwanted reactions. It is widely used in the pharmaceutical industry to aid in the construction of drugs. This specific chemical has potential applications in biochemistry and pharmaceuticals, commonly found in medical agents such as sedatives and antidepressants.

InChI:InChI=1/C11H21NO3/c1-10(2,3)15-9(13)12-7-5-11(4,14)6-8-12/h14H,5-8H2,1-4H3

Upstream product

• 676-58-4 methylmagnesium chloride 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 917-54-4 methyllithium 
• 75-16-1 methylmagnesium bromide 
• 189321-63-9 1-(tert-butoxycarbonyl)-4-methylpiperidine-4-carboxylic acid 
• 109384-19-2 t-butyl 4-hydroxy piperidine-1-carboxylate 
• 586375-35-1 4-methylpiperidin-4-ol hydrochloride 
• 24424-99-5 di-tert-butyl dicarbonate 
• 15721-22-9 2,2-dimethylvaleroyl chloride 

Downstream Products

• 1567215-32-0 (S)-methyl 2-(7-(4-(allyloxy)-4-methylpiperidin-1-yl)-2-(3-bromophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate 
• 1567215-40-0 (S)-methyl 2-(7-(4-(allyloxy)-4-methylpiperidin-1-yl)-2-(2’-(but-3-en-1-yl)[1,1‘-biphenyl]-3-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate 
• 1567215-47-7 (S)-methyl 2-(7-(4-(allyloxy)-4-methylpiperidin-1-yl)-2-(2‘-hydroxy-[1,1‘-biphenyl]-3-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate 
• 1567215-50-2 (S)-methyl 2-(7-(4-(allyloxy)-4-methylpiperidin-1-yl)-2-(2‘-(allyloxy)-[1,1‘-biphenyl]-3-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate 
• 1567215-68-2 (S)-methyl 2-(7-(4-(allyloxy)-4-methylpiperidin-1-yl)-5-methyl-2-(2‘-((R)-pent-4-en-2-yloxy)-[1,1‘-biphenyl]-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate 
• 1567215-75-1 (S)-methyl 2-(7-(4-(allyloxy)-4-methylpiperidin-1-yl)-5-methyl-2-(2‘-((S)-pent-4-en-2-yloxy)-[1,1‘-biphenyl]-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate 
• 1567215-90-0 (S)-methyl 2-(7-(4-(allyloxy)-4-methylpiperidin-1-yl)-5-methyl-2-(2‘-(pent-4-en-1-yl)-[1,1‘-biphenyl]-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate 
• 1567216-07-2 (S)-methyl 2-(7-(4-(allyloxy)-4-methylpiperidin-1-yl)-2-(2‘-hydroxy-5‘-methyl-[1,1‘-biphenyl]-3-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate 
• 1567216-24-3 (S)-methyl 2-(7-(4-(allyloxy)-4-methylpiperidin-1-yl)-2-(3-(4-(but-3-en-1-yl)pyridin-3-yl)phenyl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate 
• 1567216-89-0 (S)-methyl 2-(7-(4-(allyloxy)-4-methylpiperidin-1-yl)-5-methyl-2-(5‘-methyl-2‘-((S)-pent-4-en-2-yloxy)-[1,1‘-biphenyl]-3-yl)pyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate 
• 1567217-02-0 (2S)-methyl 2-(7-(4-(allyloxy)-4-methylpieridin-1-yl)-2-(3-(4-(but-3-en-2-yloxy)pyridin-3-yl)phenyl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate 
• 1567218-11-4 (S)-methyl 2-(7-(4-(allyloxy)-4-methylpiperidin-1-yl)-2-(2‘-hydroxy-4‘-methyl-[1,1‘-biphenyl]-3-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate 
• 1567218-32-9 (S)-methyl 2-(7-(4-(allyloxy)-4-methylpiperidin-1-yl)-2-(4’,5‘-dimethyl-2‘-((S)-pent-4-en-2-yloxy)-[1,1‘-biphenyl]-3-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate 
• 1567218-78-3 (S)-methyl 2-(7-(4-(allyloxy)-4-methylpiperidin-1-yl)-2-(2‘-hydroxy-5‘-(trifluoromethyl)-[1,1‘-biphenyl]-3-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-(tert-butoxy)acetate 

Relevant articles and documents

USES OF PHOSPHODIESTERASE INHIBITORS

-

Organophotoredox-Catalyzed Decarboxylative C(sp3)-O Bond Formation

This manuscript reports a visible-light-mediated organosulfide catalysis that enables the decarboxylative coupling between simple aliphatic alcohol and tertiary or secondary alkyl carboxylic acid-derived redox active esters to produce a C(sp3)-O-C(sp3) fragment. Results of the coupling using other heteroatom nucleophiles such as water, amides, and thiols are also described.

PDE9 inhibitor and uses thereof

The invention belongs to the technical field of medicines, particularly relates to a PDE9 inhibitor compound shown as a formula (I) or pharmaceutically acceptable salt, isomer, a deuterated compound,metabolite and prodrug thereof, and further relates to pharmaceutical preparations, pharmaceutical compositions and application of the compounds. X1, X2, X3, X4, R1, R2, ring A, L and m are defined inthe specification. The compounds can be used for preparing medicines for treating or preventing related diseases mediated by PDE9.