4072-67-7

Basic information

• Product Name: 4,4'-Bis(2-bromoacetyl)biphenyl
• Synonyms: 1,1'-[1,1'-biphenyl]-4,4'-diylbis[2-bromoethan-1-one];4,4'-Bis(2-bromoacetyl)biphenyl;2-Bromo-1-[4-[4-(2-bromoacetyl)phenyl]phenyl]ethanone;1,1'-(1,1'-Biphenyl-4,4'-diyl)bis(2-bromoethanone);4,4'-Bis(bromoacetyl)biphenyl;Einecs 223-785-3;Ethanone, 1,1'-(1,1'-biphenyl)-4,4'-diylbis(2-bromo-;4,4'-Bis(2-bromoacetyl)biphenyl 1,1'-(1,1'-Biphenyl)-4,4'-diylbis(2-bromoethan-1-one)
• CAS NO: 4072-67-7
• Molecular Formula: C₁₆H₁₂Br₂O₂
• Molecular Weight: 396.07
• EINECS: 223-785-3
• Mol File: 4072-67-7.mol
• Article Data: 27

Chemical Properties

• Melting Point: 226-227 °C(Solv: benzene (71-43-2))
• Boiling Point: 464.8 °C at 760 mmHg
• Flash Point: 121.3 °C
• Appearance: /
• Density: 1.622 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 4,4'-Bis(2-bromoacetyl)biphenyl(CAS DataBase Reference)
• NIST Chemistry Reference: 4,4'-Bis(2-bromoacetyl)biphenyl(4072-67-7)
• EPA Substance Registry System: 4,4'-Bis(2-bromoacetyl)biphenyl(4072-67-7)

Safety Data

• Hazardous Substances Data: 4072-67-7(Hazardous Substances Data)

Usage

General Description

4,4'-Bis(2-bromoacetyl)biphenyl is a chemical compound that consists of a biphenyl core with two bromoacetyl groups attached to each phenyl ring. The molecule has a molecular formula of C16H12Br2O2 and a molecular weight of 397.07 g/mol. It is primarily used as a building block in organic synthesis and as a reagent in chemical reactions, particularly in the preparation of various organic compounds. 4,4'-Bis(2-bromoacetyl)biphenyl may be used in the pharmaceutical industry and other chemical industries for the synthesis of complex molecules. It is important to handle 4,4'-Bis(2-bromoacetyl)biphenyl with caution, as it is a reactive and potentially hazardous chemical.

Upstream product

• 787-69-9 4,4'-diacetylbiphenyl 
• 99-90-1 para-bromoacetophenone 
• 99-73-0 para-bromophenacyl bromide 
• 98-80-6 phenylboronic acid 
• 92-52-4 biphenyl 
• 598-21-0 2-Bromoacetyl bromide 

Downstream Products

• 15172-86-8 4,4'-bis-[(3-methyl-pyridinio)-acetyl]-biphenyl; dibromide 
• 13717-24-3 4,4'-Bis-<-(2,2-diaethoxy-aethyl)-N,N-dimethyl-ammonioacetyl>-biphenyl-dibromid 
• 123489-63-4 4,4'-bis<(3-methylpyrrolidino)acetyl>biphenyl dimethiobromide 
• 19035-84-8 4,4'-bis-[(4-methyl-pyridinio)-acetyl]-biphenyl; dibromide 
• 20275-19-8 4,4'-bis-[(2-methyl-pyridinio)-acetyl]-biphenyl; dibromide 
• 123489-67-8 4,4'-bis(2,3,5,6-tetrahydro-1,4-oxazin-4-ylacetyl)biphenyl dimethiobromide 
• 1007882-23-6 methyl N-[(2S)-1-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]pyrrolidin-2-yl]-1H-imidazol-5-yl]phenyl]phenyl]-1H-imidazol-2-yl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate 
• 1007883-22-8 (1R,1'R)-2,2'-(4,4'-biphenyldiylbis(1H-imidazole-5,2-diyl-(4R)-1,3-thiazolidine-4,3-diyl))bis(N,N-dimethyl-2-oxo-1-phenylethanamine) 
• 1007883-19-3 (4R,4'R)-tert-butyl 4,4'-(2,2'-(biphenyl-4,4'-diyl)bis(2-oxoethane-2,1-diyl))bis(azanediyl)bis(oxomethylene)dithiazolidine-3-carboxylate 
• 1007883-20-6 (4R,4'R)-tert-butyl 4,4'-(5,5'-(biphenyl-4,4'-diyl)bis(1H-imidazole-5,2-diyl))dithiazolidine-3-carboxylate 

Relevant articles and documents

MICRO-ELECTROLYSIS REACTOR FOR ULTRA FAST, OXIDANT FREE, C-C COUPLING REACTION AND SYNTHESIS OF DACLATASVIR ANALOGS THEREOF

The present invention relates to a continuous micro-electro-flow reactor system for ultra-fast, oxidant free, C—C coupling reaction for making symmetrical biaryls and analogs thereof. This invention further relates to the said process for preparation of antiviral drug, daclatasvir of general formula I.

Facile Suzuki-Miyaura coupling of activated aryl halides using new CpNiBr(NHC) complexes

Nine new Ni(II)-NHC complexes, [CpNiBr(NHC)], were synthesised from nickelocene and the corresponding symmetric or asymmetric alkyl/-benzyl/phenylethyl imidazolium bromide ligands in relatively high yield. Access to each of the synthesised symmetric or asymmetric alkyl/benzyl/phenylethyl imidazolium bromide salts was obtained through deprotonation of imidazole, followed by treatment with an alkyl- or aryl halide, which is subsequently followed with reaction of a secondary alkyl-, benzyl-, or phenylethyl halide. The series of [CpNiBr(NHC)] exhibited catalytic activity in the Suzuki-Miyaura coupling of activated aryl halides with phenylboronic acid to give the respective biphenyl and biphenyl-containing products. In general, the more electron-donating NHC-bearing Ni complexes showed higher activity with aryl halides bearing electron-withdrawing functionalities including carboxaldehyde moieties. All complexes were characterised by 1H and 13C NMR spectroscopy, FT-IR spectroscopy, CHN and MS analyses, along with six selected single crystal X-ray structures that are reported here.

Daclatasvir synthetic method

The invention provides a daclatasvir synthetic method. The method comprises the following steps: taking 4,4'-di(2-halogenated acetyl)biphenyl as a raw material, performing an esterification reaction with N-(methoxycarbonyl)-L-valine-L-proline in an organic solvent under alkali existence to obtain an intermediate B; then performing a dehydrating-cyclizing reaction on the intermediate B and ammonium acetate in an xylene solution at the temperature of 100-120 DEG C to obtain free alkali C; and reacting the free alkali C and HCl to obtain a daclatasvir crude product; and finally re-crystallizing the daclatasvir crude product to obtain daclatasvir. The synthetic method has the advantages of simple synthesis route, convenient operation and simple purifying, the purity of daclatasvir obtained by the synthesis reaction is high, the yield is large, quality of the daclatasvir bulk drug is greatly increased, production cost is reduced, and the method is suitable for large industrial production.