40742-21-0Relevant articles and documents
Aryl Ether Syntheses via Aromatic Substitution Proceeding under Mild Conditions
Ando, Shin,Tsuzaki, Marina,Ishizuka, Tadao
, p. 11181 - 11189 (2020/10/12)
In this study, mild conditions for aromatic substitutions during the syntheses of aryl ethers were developed. In the reaction conditions, the choices of solvent, base, and the sequence for the addition of the reagents proved important. A wide variety of alcohols were used directly as nucleophiles and smoothly reacted with aryl chlorides that possessed either a nitro or a cyano group at either the ortho- or para-position. Controlled experiments we performed suggested that the reaction underwent a charge-transfer process mediated by a combination of DMF and tert-BuOK.
Widely Applicable Hydrofluorination of Alkenes via Bifunctional Activation of Hydrogen Fluoride
Lu, Zhichao,Zeng, Xiaojun,Hammond, Gerald B.,Xu, Bo
supporting information, p. 18202 - 18205 (2017/12/28)
Expanding the use of fluorine in pharmaceuticals, agrochemicals and materials requires a widely applicable and more efficient protocol for the preparation of fluorinated compounds. We have developed a new generation nucleophilic fluorination reagent, KHSO4-13HF, HF 68 wt/wt %, that is not only easily handled and inexpensive but also capable of hydrofluorinating diverse, highly functionalized alkenes, including natural products. The high efficiency observed in this reaction hinges on the activation of HF using a highly "acidic" hydrogen bond acceptor.
Deprotection of homoallyl (hAllyl) derivatives of phenols, alcohols, acids, and amines
Lipshutz, Bruce H.,Ghorai, Subir,Leong, Wendy Wen Yi
supporting information; experimental part, p. 2854 - 2857 (2009/08/08)
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