4078-54-0

Basic information

• Product Name: 2-(2-Bromoethyl)benzoimidazole
• Synonyms: 2-(2-BROMOETHYL)BENZIMIDAZOLE;2-(2-Bromoethyl)benzoimidazole;2-(2-Bromoethyl)-1H-benzoimidazole;2-(2-bromoethyl)-1H-benzo[d]imidazole
• CAS NO: 4078-54-0
• Molecular Formula: C9H9BrN2
• Molecular Weight: 225.09
• Mol File: 4078-54-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 401.8 °C at 760 mmHg
• Flash Point: 196.8 °C
• Appearance: /
• Density: 1.595 g/cm³
• Vapor Pressure: 2.66E-06mmHg at 25°C
• Refractive Index: 1.689
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-(2-Bromoethyl)benzoimidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-Bromoethyl)benzoimidazole(4078-54-0)
• EPA Substance Registry System: 2-(2-Bromoethyl)benzoimidazole(4078-54-0)

Safety Data

• Hazardous Substances Data: 4078-54-0(Hazardous Substances Data)

Usage

General Description

2-(2-Bromoethyl)benzoimidazole is a chemical compound that belongs to the benzimidazole family. It is a white to off-white solid substance that is soluble in organic solvents. 2-(2-Bromoethyl)benzoimidazole has been used in various research studies and can be synthesized through different chemical reactions. Its chemical structure contains a benzene ring fused to an imidazole ring with a 2-bromoethyl group attached to the benzene ring. It has been studied for its potential pharmaceutical applications and as a building block for the synthesis of other compounds. This chemical compound should be handled and used with proper precautions and in accordance with established safety guidelines.

InChI:InChI=1/C9H9BrN2/c10-6-5-9-11-7-3-1-2-4-8(7)12-9/h1-4H,5-6H2,(H,11,12)

Upstream product

• 51036-80-7 2-(2-ethoxy-ethyl)-1H-benzimidazole 
• 590-92-1 3-Bromopropionic acid 
• 95-54-5 1,2-diamino-benzene 

Relevant articles and documents

Discovery of novel heteroarylmethylcarbamodithioates as potent anticancer agents: Synthesis, structure-activity relationship analysis and biological evaluation

A series of new analogs based on the structure of lead compound 10 were designed, synthesized and evaluated for their in vitro anti-cancer activities against four selected human cancer cell lines (HL-60, Bel-7402, SK-BR-3 and MDA-MB-468). Several synthesized compounds exhibited improved anti-cancer activities comparing with lead compound 10. Among them, 1,3,4-oxadiazole analogs 17o showed highest bioactivity with IC50 values of 1.23, 0.58 and 4.29 μM against Bel-7402, SK-BR-3 and MDA-MB-468 cells, respectively. It is noteworthy that 17o has potent anti-proliferation activity toward a panel of cancer cells with relatively less cytotoxicity to nonmalignant cells. The further mechanistic study showed that it induced apoptosis and cell cycle arrest through disrupting spindle assembly in mitotic progression, indicating these synthesized dithiocarbamates represented a novel series of anti-cancer compounds targeting mitosis.