4078-65-3

Basic information

• Product Name: N-(3,4-Dimethoxyphenethyl)-2-(4-methoxyphenyl)acetamide
• Synonyms: GS-354;N-(3,4-Dimethoxyphenethyl)-2-(4-methoxyphenyl)acetamide;N-(3,4-Dimethoxyphenethyl)-4-methoxybenzeneacetamide;N-(2,4-DiMethoxyphenethyl)-2-(4-Methoxyphenyl)acetaMide
• CAS NO: 4078-65-3
• Molecular Formula: C₁₉H₂₃NO₄
• Molecular Weight: 329.39
• Mol File: 4078-65-3.mol
• Article Data: 15

Chemical Properties

• Melting Point: 126-128 °C
• Boiling Point: 541.6±50.0 °C(Predicted)
• Appearance: /
• Density: 1.120±0.06 g/cm3(Predicted)
• Solubility: Chloroform
• PKA: 15.53±0.46(Predicted)
• CAS DataBase Reference: N-(3,4-Dimethoxyphenethyl)-2-(4-methoxyphenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3,4-Dimethoxyphenethyl)-2-(4-methoxyphenyl)acetamide(4078-65-3)
• EPA Substance Registry System: N-(3,4-Dimethoxyphenethyl)-2-(4-methoxyphenyl)acetamide(4078-65-3)

Safety Data

• Hazardous Substances Data: 4078-65-3(Hazardous Substances Data)

Usage

Uses

N-(2,4-Dimethoxyphenethyl)-2-(4-methoxyphenyl)acetamide is an intermediate in the synthesis of (-)-Higenamine (H325800).

Upstream product

• 104-01-8 4-Methoxyphenylacetic acid 
• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 4230-93-7 1,2-dimethoxy-4-(2-nitro-vinyl)-benzene 
• 1798-09-0 m-methoxyphenylacetic acid 
• 6834-42-0 3-methoxyphenylacetic acid chloride 
• 4693-91-8 4-methoxyphenyl-acetic chloride 

Downstream Products

• 3991-23-9 6,7-dimethoxy-1-(4-methoxy-benzyl)-2-methyl-3,4-dihydro-isoquinolinium; iodide 
• 41498-37-7 7,12-O,O'-dimethylcoclaurine 
• 17052-80-1 (6,7-dimethoxy-3,4-dihydroisoquinolin-1-yl)(4-methoxyphenyl)-methanone 
• 1443828-59-8 ((3-chlorophenyl)(6,7-dimethoxy-1-(4-methoxybenzyl)-3,4-dihydroisoquinolin-2(1H)-yl)methanone) 
• 1443828-58-7 ((6,7-dimethoxy-1-(4-methoxybenzyl)-3,4-dihydroisoquinolin-2(1H)-yl)(phenyl)methanone) 
• 1443828-60-1 ((6,7-dimethoxy-1-(3-methoxybenzyl)-3,4-dihydroisoquinolin-2(1H)-yl)(phenyl)methanone) 
• 13233-00-6 6,7-dimethoxy-1-(4-methoxybenzyl)-3,4-dihydroisoquinoline hydrochloride 
• 81165-37-9 3-[6,7-Dimethoxy-1-(4-methoxy-benzyl)-3,4-dihydro-1H-isoquinolin-2-yl]-propionic acid 2-{3-[6,7-dimethoxy-1-(4-methoxy-benzyl)-3,4-dihydro-1H-isoquinolin-2-yl]-propionyloxy}-ethyl ester; compound with oxalic acid 
• 64229-29-4 C₄₈H₆₂N₂O₁₀⁽²⁺⁾*2I^(1-) 
• 77354-33-7 (+/-)-1-(4-methoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochoride 
• 72527-29-8 6,7-dimethoxy-1-(4-methoxybenzyl)-3,4-dihydroisoquinoline 

Relevant articles and documents

Synthesis of N-Heterocycles by Reductive Cyclization of Nitroalkenes Using Molybdenum Hexacarbonyl as Carbon Monoxide Surrogate

The development of a method that uses molybdenum hexacarbonyl [Mo(CO)6] as carbon monoxide (CO) surrogate for the palladium-catalyzed reductive cyclization of nitroalkenes into indoles or thienopyrroles is reported. Several types of nitroalkenes could be transformed into the desired products in excellent yields and in most cases with complete regioselectivities and higher yields than those previously reported with palladium/CO system.

Tetrahydroisoquinoline derivative and application thereof

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Synthesis and structure activity relationship of tetrahydroisoquinoline- based potentiators of GluN2C and GluN2D containing N-Methyl-D-aspartate receptors

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