40811-69-6Relevant articles and documents
Design, synthesis and biological evaluation of oxindole-based chalcones as small-molecule inhibitors of melanogenic tyrosinase
Suthar, Sharad Kumar,Bansal, Sumit,Narkhede, Niteen,Guleria, Manju,Alex, Angel Treasa,Joseph, Alex
, p. 833 - 839 (2017)
The enzyme tyrosinase regulates melanogenesis and skin hyperpigmentation by converting L-3,4-dihy-droxyphenylalanine (L-DOPA) into dopaquinone, a key step in the melanin biosynthesis. The present work deals with design and synthesis of various oxindole-ba
Gif-2209, an oxindole derivative, accelerates melanogenesis and melanosome secretion via the modification of lysosomes in b16f10 mouse melanoma cells
Furuta, Kyoji,Kawaguchi, Kyoka,Nakamura, Yusuke,Takemori, Hiroshi,Watanabe, Miyu
, (2022/01/04)
Melanogenesis and melanosome secretion are regulated by several mechanisms. In this study, we found that the oxindole derivative GIF-2209 accelerated melanogenesis associated with the discrimination in the expression and intracellular distributions of two
Piers-rubinsztajn reaction and the application in siloxane/polysiloxane chemistry
Patel, Chetananda,Kumar, Amit,Patil, Pooja,Sharma, Abha
supporting information, p. 600 - 605 (2019/08/08)
An efficient synthesis of biologically important benzylidene-indolin-2-one derivatives using meglumine as green catalyst and ethanol:water as reaction media at 78°C has been developed. The effects of reaction conditions such as solvents, temperature, and amount of catalyst were investigated. The present methodology offers many advantages such as simple procedure, less time taking to complete the reaction, high yield of products, and clean reaction profile.
