408359-06-8

Basic information

• Product Name: 3-bromo-N-tosylpyrrole-2-carboxaldehyde
• Synonyms: 3-bromo-N-tosylpyrrole-2-carboxaldehyde
• CAS NO: 408359-06-8
• Molecular Weight: 328.186
• Mol File: 408359-06-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-bromo-N-tosylpyrrole-2-carboxaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 3-bromo-N-tosylpyrrole-2-carboxaldehyde(408359-06-8)
• EPA Substance Registry System: 3-bromo-N-tosylpyrrole-2-carboxaldehyde(408359-06-8)

Safety Data

• Hazardous Substances Data: 408359-06-8(Hazardous Substances Data)

Upstream product

• 137845-37-5 4-methyl-N-((1E,2E)-3-phenylallylidene)benzenesulfonamide 
• 70-55-3 toluene-4-sulfonamide 
• 168030-84-0 (E)-3-bromo-1-tosyl-2-styrylpyrrole 

Downstream Products

• 933790-07-9 3-ethenyl-N-tosylpyrrole-2-carbaldehyde 
• 933790-09-1 7-hydroxy-6-methyl-N-tosylindole 
• 933790-05-7 7-(methoxymethyloxy)-6-methyl-N-tosylindole 
• 933790-06-8 3-ethenyl-2-[1-(methoxymethyloxy)prop-2-yn-1-yl]-N-tosylpyrrole 
• 933790-08-0 3-ethenyl-2-(1-hydroxyprop-2-yn-1-yl)-N-tosylpyrrole 
• 933790-10-4 6-methyl-N-tosylindole-4,7-dione 
• 872327-47-4 3-phenylethynyl-1-(toluene-4-sulfonyl)-1H-pyrrole-2-carbaldehyde 
• 872327-46-3 3-(1-hexynyl)-N-tosylpyrrole-2-carboxaldehyde 
• 408359-07-9 3-bromo-1H-pyrrole-2-carbaldehyde 

Relevant articles and documents

Studies of palladium-catalyzed coupling reactions for preparation of hindered 3-arylpyrroles relevant to (-)-rhazinilam and its analogues

Suzuki cross-coupling reactions of 3-pyrroleboronic acid derivatives with haloaromatics and the reverse process i.e., the coupling of 3-iodo(bromo)pyrroles with arylboronic acids have been investigated as a potential key step in the synthesis of (-)-rhazinilam and analogues. It was found that 3-iodo-2-formyl-1-tosylpyrroles efficiently coupled with a variety of arylboronic acids in the presence of PdCl2(dppf) as catalyst. This catalytic system is compatible with a broad spectrum of arylboronic acids - electron-rich, electron-poor, hindered, heterocyclic - which easily coupled with the pyrrole substrate.