408523-30-8

Basic information

• Product Name: 3-METHYLQUINOLINE-2-CARBOXALDEHYDE
• Synonyms: 3-METHYLQUINOLINE-2-CARBOXALDEHYDE;3-Methylquinoline-2-carbaldehyde;3-methyl-2-Quinolinecarboxaldehyde;2-Quinolinecarboxaldehyde, 3-methyl-;3-Methylquinoline-2-Carboxaldehyde(WX624088)
• CAS NO: 408523-30-8
• Molecular Formula: C11H9NO
• Molecular Weight: 171.19526
• Mol File: 408523-30-8.mol
• Article Data: 3

Chemical Properties

• Melting Point: 114-115 °C
• Boiling Point: 330.4°C at 760 mmHg
• Flash Point: 161.7°C
• Appearance: /
• Density: 1.183g/cm³
• Vapor Pressure: 0.000166mmHg at 25°C
• Refractive Index: 1.665
• Storage Temp.: 2-8°C
• PKA: 3.82±0.50(Predicted)
• CAS DataBase Reference: 3-METHYLQUINOLINE-2-CARBOXALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-METHYLQUINOLINE-2-CARBOXALDEHYDE(408523-30-8)
• EPA Substance Registry System: 3-METHYLQUINOLINE-2-CARBOXALDEHYDE(408523-30-8)

Safety Data

• Hazardous Substances Data: 408523-30-8(Hazardous Substances Data)

Usage

General Description

3-Methylquinoline-2-carboxaldehyde is a chemical compound with the molecular formula C11H9NO. It is an organic compound that belongs to the class of quinoline derivatives, which are heterocyclic compounds containing a benzene ring fused to a pyridine ring. 3-Methylquinoline-2-carboxaldehyde is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. Its structure contains a carbonyl group (aldehyde) attached to the 2-position of the quinoline ring, making it a versatile building block for the preparation of various biologically active molecules. 3-METHYLQUINOLINE-2-CARBOXALDEHYDE is also known for its strong, pungent odor and it is often used in the flavor and fragrance industry.

InChI:InChI=1/C11H9NO/c1-8-6-9-4-2-3-5-10(9)12-11(8)7-13/h2-7H,1H3

Upstream product

• 1721-89-7 2,3-dimethylquinoline 
• 7446-08-4 selenium(IV) oxide 
• 108-38-3 m-xylene 
• 67-56-1 methanol 
• 612-58-8 3-methylquinoline 

Relevant articles and documents

Methanol as a formylating agent in nitrogen heterocycles

A radical mediated C-H direct formylation of N-heteroarenes with methanol is reported. The reaction features a novel iron-catalyzed Minisci oxidative coupling process using commercially available methanol as a formylating reagent. It effectively solved the long-standing problems associated with using methanol as a formylating reagent in these types of reactions. Compared to the traditional Minisci C-H formylation methods, this protocol is highly atom-economical, simple to operate, and environmentally friendly and shows good functional group tolerance. This Minisci formylation strategy is a straightforward approach for the late-stage functionalization of N-heteroarenes. This journal is

Chemical synthesis method of quinoline (oxaline)-2-carboxaldehyde compounds

The invention relates to a preparation method of quinoline (oxaline)-2-carboxaldehyde compounds. The preparation method comprises the following steps of dissolving 2-methylquinoline(oxaline) shown in a formula (II) into an organic solvent, adding iron salts, and completely reacting under the condition of 100 to 180DEG C with the assistance of microwave; performing after treatment on a reaction solution to obtain the quinoline (oxaline)-2-carboxaldehyde compounds shown in a formula (I), wherein the feed molar ratio of the iron salts to the quinoline (oxaline)-2-carboxaldehyde compounds is (0.5 to 3.5):1. R in the formula (I) and the formula (II) is hydrogen at the same time; or the hydrogen is monosubstituted or polysubstituted by alkyls of C1 to C8, alkoxys of C1 to C8, nitryl or halogen; the number of substituent groups is n; X in the formula (I) and the formula (II) is carbon or nitrogen at the same time. The preparation method disclosed by the invention has the advantages of short reaction time, low reaction temperature, wide application range of reaction, good reaction selectivity, low price and no toxicity of a used catalyst, and simplicity and convenience in operation; the preparation method meets the requirement of green chemistry. (The formulas are shown in the description).