40891-33-6

Basic information

• Product Name: 3,5-diMethoxyaniline hydrochloride
• Synonyms: 3,5-diMethoxyaniline hydrochloride;Benzenamine, 3,5-dimethoxy-, hydrochloride (1:1);3,5-Dimethoxybenzenamine hydrochloride;Benzenamine, 3,5-dimethoxy-, hydrochloride;3,5-DIMETHOXYANILINE HCL
• CAS NO: 40891-33-6
• Molecular Formula: C₈H₁₁NO₂*ClH
• Molecular Weight: 189.63938
• Mol File: 40891-33-6.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 302.9°Cat760mmHg
• Flash Point: 142.4°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 0.000963mmHg at 25°C
• CAS DataBase Reference: 3,5-diMethoxyaniline hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-diMethoxyaniline hydrochloride(40891-33-6)
• EPA Substance Registry System: 3,5-diMethoxyaniline hydrochloride(40891-33-6)

Safety Data

• Hazardous Substances Data: 40891-33-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H11NO2.ClH/c1-10-7-3-6(9)4-8(5-7)11-2;/h3-5H,9H2,1-2H3;1H

Upstream product

• 10272-07-8 3.5-dimethoxyaniline 

Downstream Products

• 21544-81-0 4,6-dimethoxyindoline-2,3-dione 
• 887468-94-2 7-methoxy-3-(4-methoxy-phenyl)-5-methyl-3H-quinazoline-4-thione 
• 887468-75-9 7-methoxy-3-(4-methoxy-phenyl)-5-methyl-3H-quinazolin-4-one 
• 887468-86-2 5-amino-7-methoxy-3-(4-methoxy-phenyl)-3H-quinazolin-4-one 
• 628687-05-8 5-hydroxy-7-methoxy-3-(4-methoxyphenyl)-4(3H)-quinazolinone 
• 628687-02-5 5,7-dimethoxy-3-(4-methoxyphenyl)-4(3H)-quinazolinethione 
• 628686-89-5 5,7-dimethoxy-3-(4-methoxyphenyl)-4(3H)-quinazolinone 
• 887468-88-4 7-methoxy-3-(4-methoxy-phenyl)-4-oxo-3,4-dihydro-quinazoline-5-carbonitrile 
• 628687-04-7 5,7-dihydroxy-3-(4-hydroxyphenyl)-4(3H)-quinazolinone 
• 628686-90-8 5,7-dimethoxy-2-methyl-3-(4-methoxyphenyl)-4(3H)-quinazolinone 
• 887468-96-4 5-ethyl-7-methoxy-3-(4-methoxy-phenyl)-3H-quinazoline-4-thione 

Relevant articles and documents

Synthesis of dipyrrolo[2,3-a:1′,2′,3′-fg]acridin-12(1H)-ones

Acylation reactions of 4,6-dimethoxyindoles with glyoxyloyl chlorides were achieved by the use of graphite powder in 1,2-dichloroethane at reflux. The products were monoketones as a result of decarbonylation, rather than the expected 1,2-diketones. Treatment of these monoketones with base led to their cyclisation and elimination of methanol to afford the novel dipyrrolo[2.3-a:1′,2′,3′-fg]acridin-12(1H)-ones.

Discovery of Novel Dual-Target Inhibitor of Bromodomain-Containing Protein 4/Casein Kinase 2 Inducing Apoptosis and Autophagy-Associated Cell Death for Triple-Negative Breast Cancer Therapy

Bromodomain-containing protein 4 (BRD4) is an attractive epigenetic target in human cancers. Inhibiting the phosphorylation of BRD4 by casein kinase 2 (CK2) is a potential strategy to overcome drug resistance in cancer therapy. The present study describes the synthesis of multiple BRD4–CK2 dual inhibitors based on rational drug design, structure–activity relationship, and in vitro and in vivo evaluations, and 44e was identified to possess potent and balanced activities against BRD4 (IC50 = 180 nM) and CK2 (IC50 = 230 nM). In vitro experiments show that 44e could inhibit the proliferation and induce apoptosis and autophagy-associated cell death of MDA-MB-231 and MDA-MB-468 cells. In two in vivo xenograft mouse models, 44e displays potent anticancer activity without obvious toxicities. Taken together, we successfully synthesized the first highly effective BRD4–CK2 dual inhibitor, which is expected to be an attractive therapeutic strategy for triple-negative breast cancer (TNBC).

Used for the prevention and treatment of cardiovascular diseases

The invention relates to compounds that can be used for adjusting the expression of apolipoprotein A-I (ApoA-I) and usage of the compounds in treating and preventing cardiovascular diseases and related diseases, including the disorder related to cholesterol or lipids such as atherosclerosis.