40896-62-6Relevant articles and documents
Compounds having beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity
-
Page/Page column 44, (2008/06/13)
The invention is directed to compounds of formula I: wherein R1, R2, R3, R4, R5, R6, R7a, R7b, W, G1, G2, a, b, c, d and m are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The invention is also directed to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
Azabicycloalkane compounds
-
Page 35-36, (2008/06/13)
This invention provides compounds of formula I: wherein R1, R2, R3, R4, R5, R6 and R7 are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The compounds of this invention possess both β2 adrenergic receptor agonist and muscarinic receptor antagonist activity. Such compounds are useful for treating pulmonary disorders, such as chronic obstructive pulmonary disease and asthma.
Substituent effects. 14. Anomalous dissociation constants in water-organic solvent mixtures: benzylammonium ions and related systems
Hoefnagel, A. J.,Vos, R. H. de,Wepster, B. M.
, p. 22 - 28 (2007/10/02)
Thermodynamic dissociation constants in various water-organic solvent mixtures are given for benzylammonium, benzyldialkylammonium, and (2-phenylethyl)ammonium ions.Deviations from the Hammett equation (Eqn. 1) are similar to those observed for carboxylic acids, but of opposite sign.The extended Hammett equation (Eqn. 3), containing the hydrophobic constant, ?, yields good correlations.Derived secondary normal sigma values are exemplified.