40941-54-6

Basic information

• Product Name: 4,7-dimethylquinoline
• Synonyms: 4,7-dimethylquinoline
• CAS NO: 40941-54-6
• Molecular Formula: C₁₁H₁₁N
• Molecular Weight: 157.21174
• EINECS: 255-148-0
• Mol File: 40941-54-6.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 271.88°C (rough estimate)
• Flash Point: 115.5°C
• Appearance: /
• Density: 1.0595 (rough estimate)
• Vapor Pressure: 0.00555mmHg at 25°C
• Refractive Index: 1.6722 (estimate)
• CAS DataBase Reference: 4,7-dimethylquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 4,7-dimethylquinoline(40941-54-6)
• EPA Substance Registry System: 4,7-dimethylquinoline(40941-54-6)

Safety Data

• Hazardous Substances Data: 40941-54-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H11N/c1-8-3-4-10-9(2)5-6-12-11(10)7-8/h3-7H,1-2H3

Upstream product

• 638-03-9 m-toluidine hydrochloride 
• 78-94-4 methyl vinyl ketone 
• 108-44-1 1-amino-3-methylbenzene 
• 2585-18-4 4,7-dimethyl-quinolin-2-ol 
• 18826-95-4 1.3-butanediol 
• 1179812-15-7 4-[(3-methylphenyl)amino]butan-2-one 
• 2585-18-4 4,7-dimethyl-1,2-dihydroquinolin-2-one 
• 86-98-6 4,7-dichloroquinoline 
• 75-16-1 methylmagnesium bromide 

Downstream Products

• 110244-28-5 N,N-dimethyl-4-[trans-2-(7-methyl-[4]quinolyl)-vinyl]-aniline 

Relevant articles and documents

Metal-Free Chemoselective Oxidation of 4-Methylquinolines into Quinoline-4-Carbaldehydes

A convenient protocol for the synthesis of quinoline-4-carbaldehydes via chemoselective oxidation of 4-methylquinolines using hypervalent iodine(III) reagents as oxidant is described. This method highlights metal-free and mild reaction conditions, nice yield, good functional group tolerance, and high chemoselectivity.

Palladium-catalyzed aerobic oxidative coupling of allylic alcohols with anilines in the synthesis of nitrogen heterocycles

We report herein an unprecedented and expedient Pd-catalyzed oxidative coupling of allyl alcohols with anilines to afford β-amino ketones which are converted into substituted quinolines in a one-pot fashion. The exclusive preference for N-alkylation over N-allylation makes this approach unique when compared to those reported in literature. Detailed mechanistic investigations reveal that the conjugate addition pathway was the predominant one over the allylic amination pathway. The notable aspects of the present approach are the use of readily available, bench-stable allyl alcohols and molecular oxygen as the terminal oxidant, in the process dispensing the need for unstable and costly enones. Further, we explored the synthetic utility of β-amino ketones through an intramolecular α-arylation methodology and a one-pot domino annulation, thereby providing rapid access to indolines and quinolines.

Solvent-promoted and -controlled Aza-Michael reaction with aromatic amines

(Chemical Equation Presented) 1,4-Addition of anilines onto Michael acceptors proceeds easily in specific polar protic solvents, without any promoting agent. According to the solvent and to the electrophile, the selectivity of the reaction can be finely tuned. With methyl acrylate as electrophile, only monoaddition takes place in water, while the diadduct is yielded in hexafluoroisopropyl alcohol (HFIP). The use of methyl vinyl ketone as a partner affords the monoadduct in water, the diadduct in trifluoroethanol (TFE), and the quinoline in HFIP.