4097-49-8

Basic information

• Product Name: 4-tert-Butyl-2,6-dinitrophenol
• Synonyms: AKOS BC-0676;4-TERT-BUTYL-2,6-DINITROPHENOL;2,6-DINITRO-4-TERT-BUTYLPHENOL;LABOTEST-BB LT00160050;(TERT)BUTYLDINITROPHENOL;4-TERT-BUTYL-2,6-DINITROPHENOL 97%;4-TERT-BUTYL-2,6-DINITROPHENOL 99+%;2,6-Dinitro-p-(tert-butyl)phenol
• CAS NO: 4097-49-8
• Molecular Formula: C₁₀H₁₂N₂O₅
• Molecular Weight: 240.21
• EINECS: 223-856-9
• Product Categories: Industrial/Fine Chemicals;Aromatic Phenols
• Mol File: 4097-49-8.mol
• Article Data: 11

Chemical Properties

• Melting Point: 93-96°C
• Boiling Point: 273.6 °C at 760 mmHg
• Flash Point: 109.3 °C
• Appearance: /
• Density: 1.348 g/cm³
• Vapor Pressure: 0.00339mmHg at 25°C
• Refractive Index: 1.583
• BRN: 1986466
• CAS DataBase Reference: 4-tert-Butyl-2,6-dinitrophenol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-tert-Butyl-2,6-dinitrophenol(4097-49-8)
• EPA Substance Registry System: 4-tert-Butyl-2,6-dinitrophenol(4097-49-8)

Safety Data

• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36
• RIDADR: 2811
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 4097-49-8(Hazardous Substances Data)

Usage

General Description

4-tert-Butyl-2,6-dinitrophenol, also known as Dinitro, is a chemical compound predominantly used in the manufacturing of dyes, wood preservatives, and explosives due to its outstanding oxidizing properties. It is a yellow, crystalline solid that is not soluble in water but can dissolve in acetone or benzene. 4-tert-Butyl-2,6-dinitrophenol frequently serves as the basis for various herbicides, and at times, as a fungicide. However, due to its high reactivity and possible harmful effects on humankind’s health when interacted with, it must be handled with utmost care. It can cause adverse health effects such as skin irritation, eye damage, and respiratory complications if wrongly managed or exposed.

InChI:InChI=1/C10H12N2O5/c1-10(2,3)6-4-7(11(14)15)9(13)8(5-6)12(16)17/h4-5,13H,1-3H3

Upstream product

• 98-54-4 para-tert-butylphenol 
• 88-18-6 2-tert-Butylphenol 
• 7664-93-9 sulfuric acid 
• 7697-37-2 nitric acid 

Downstream Products

• 33629-47-9 Amchem 70-25 
• 1594135-20-2 2-(benzyloxy)-5-(tert-butyl)-1,3-dinitrobenzene 
• 1594135-18-8 C₄₀H₄₀Cl₂N₁₀O₂ 
• 1594135-19-9 2-(benzyloxy)-5-(tert-butyl)benzene-1,3-diamine 
• 214354-73-1 tetrabutyl-ammonium 2,6-dinitro-4-tert-butyl-phenolate 

Relevant articles and documents

Iodine(III)-Catalyzed Electrophilic Nitration of Phenols via Non-Br?nsted Acidic NO2+ Generation

The first catalytic procedure for the electrophilic nitration of phenols was developed using iodosylbenzene as an organocatalyst based on iodine(III) and aluminum nitrate as a nitro group source. This atom-economic protocol occurs under mild, non-Br?nsted acidic and open-flask reaction conditions with a broad functional-group tolerance including several heterocycles. Density functional theory (DFT) calculations at the (SMD:MeCN)Mo8-HX/(LANLo8+f,6-311+G) level indicated that the reaction proceeds through a cationic pathway that efficiently generates the NO2+ ion, which is the nitrating species under neutral conditions.

NOVEL BENZAMIDES, PRODUCTION THEREOF, AND USE THEREOF AS MEDICAMENTS

Heteroaryloxy-substituted benzoic acid amides of general formula I wherein the groups R1 to R7 as well as X and Y are defined according to claim 1, including the tautomers, the stereoisomers, the mixtures and the salts thereof. The compounds according to the invention are suitable for the treatment of respiratory complaints, particularly COPD and asthma.

CYTOKINE INHIBITORS

The present invention provides low molecular weight compounds useful as cytokine inhibitors, and compositions thereof. In particular, compounds of the invention are useful as anti-inflammatory agents. There are further provided methods for the preparation of such agents and their use in preventing or treating conditions mediated by cytokines, such as for example arthritis, pain, cardiovascular disease and cancer.