4097-61-4Relevant articles and documents
Nitration method for aryl phenol or aryl ether derivative
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Paragraph 0119-0124; 0128-0130, (2020/01/03)
The invention relates to a nitration method for an aryl phenol or aryl ether derivative. The method comprises the steps of stirring an aryl phenol or aryl ether compound, nitrate, trimethylchlorosilane (TMSCl) and a copper salt in an acetonitrile solution in air at room temperature, simultaneously, monitoring extent of reaction through a TLC dot plate, removing a solvent from a mixture by a rotaryevaporator after a substrate is consumed completely, and carrying out purification through a silica-gel column, thereby obtaining a nitroolefin derivative. Meanwhile, the selective mono-nitration orbis-nitration of the substrate can be achieved through controlling equivalent weight of the nitrate. Compared with the prior art, the nitration method disclosed by the invention has the advantages that the consumption of strong-acid substances is avoided, the reaction conditions are mild, the yield is high, the applicable range of the substrate is wide, reaction activity is free of obvious attenuation after an amplified reaction, and an excellent yield is still obtained, so that the method has an obvious industrial application value.
Process for 3,4-disubstituted dinitroanilines
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, (2008/06/13)
Preparation process for 3,4-disubstituted dinitroanilines of formula STR1 in which, R1 and R2, which are identical to or different from one another, represent a hydrogen atom, a C1 to C6 saturated, linear or branched alkyl radical, a C2 to C6 linear or br
Novel process to prepare N-alkyl-3,4-dialkyl-2,6-dinitroanilines
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, (2008/06/13)
A process is provided for preparing N-alkyl-3,4-dialkyl-2,6-dinitroanilines of the formula Wherein R1 is hydrogen, C1 to C6 straight or branched chain alkyl group; and, R2, R3 and R4 are independently C1 to C6 straight or branched chain alkyl group optionally substituted by one or more halogen groups, wherein a. 3,4-dialkyl phenol of the formula is selectively nitrated with nitric acid in a two phase system to form 3,4-dialkyl-2,6-dinitrophenol of the formula: b. the 3,4-dialkyl-2,6-dinitrophenol is alkylated with an alkylating agent in the presence of a base and a catalytic amount of a phase transfer catalyst chosen from the group consisting of, , (R')4Q X-, , wherein R' may be the same or different C1 to C16 straight or branched alkyl groups, benzyl, substituted benzyl; Qis N or P; and Xis CL, Br, I or HSO4; a macrocyclic ether and polyethylene glycols of formula, , HO - (CH2CH2O-)n-CH2CH2OH, , where n is an integer from 10 to 50, in an organic solvent to form 3,4-dalkyl-2,6-dinitro alkoxybenzene of the formula: where R5 is an alkyl group having 1 to 6 carbon atoms. c. the 3,4-dialkyl-2,6-dinitro alkoxybenzene is reacted with an amine of the formula where R1 and R2 are defined above, in the presence of a catalytic amount of base or halide to form N-alkyl-3,4-dialkyl-2,6-dinitroaniline. d. the N-alkyl-3,4-dialkyl-2,6-dinitroaniline is recovered.