40971-36-6

Basic information

• Product Name: 1,2,3,4-Tetrahydro-2-quinolinemethanol
• Synonyms: 1,2,3,4-Tetrahydro-2-quinolinemethanol;(1,2,3,4-tetrahydroquinolin-2-yl)methanol;2-Hydroxymethyl-1,2,3,4-tetrahydroquinoline;(2S)-1,2,3,4-Tetrahydro-2-quinolinylMethanol;2-Quinolinemethanol, 1,2,3,4-tetrahydro-;(1,2,3,4-Tetrahydroquinolin-2-yl)
• CAS NO: 40971-36-6
• Molecular Formula: C₁₀H₁₃NO
• Molecular Weight: 163.21632
• EINECS: -0
• Mol File: 40971-36-6.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 327.731 °C at 760 mmHg
• Flash Point: 163.332 °C
• Appearance: /
• Density: 1.081
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1,2,3,4-Tetrahydro-2-quinolinemethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,3,4-Tetrahydro-2-quinolinemethanol(40971-36-6)
• EPA Substance Registry System: 1,2,3,4-Tetrahydro-2-quinolinemethanol(40971-36-6)

Safety Data

• Hazardous Substances Data: 40971-36-6(Hazardous Substances Data)

Usage

General Description

1,2,3,4-Tetrahydro-2-quinolinemethanol is a chemical compound with the molecular formula C10H13NO. It is a white to off-white crystalline powder that is soluble in water and organic solvents. 1,2,3,4-Tetrahydro-2-quinolinemethanol is commonly used as a reagent in organic synthesis and as an intermediate in the manufacture of pharmaceuticals and agrochemicals. It has also been studied for its potential use as a chiral auxiliary in asymmetric synthesis. In addition, 1,2,3,4-Tetrahydro-2-quinolinemethanol has been investigated for its pharmacological properties, including its potential as a pain reliever and antimalarial agent. Overall, this compound has a wide range of uses and applications across various industries.

Upstream product

• 91-63-4 2-methylquinoline 
• 5470-96-2 quinoline 2-carbaldehyde 
• 24544-04-5 2,6-diisopropylbenzenamine 
• 62-53-3 aniline 

Downstream Products

• 618113-62-5 2-Iodomethyl-1,2,3,4-tetrahydro-quinoline 
• 1780-17-2 quinolin-2-ylmethanol 
• 1018826-31-7 [1-(3,4-dichloro-phenylsulfonyl)-1,2,3,4-tetrahydro-quinolin-2-yl]-methanol 
• 1018826-75-9 (1-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydroquinolin-2-yl)methanol 
• 185854-45-9 2-(1,2,3,4-tetrahydroquinolin-2-yl)acetic acid 
• 150533-87-2 6-bromo-5-<(methoxycarbonyl)methyl>-6,7-dihydro-1H,5H-pyrido<1,2,3-de>quinoxaline-2,3-dione 

Relevant articles and documents

Consecutive Intermolecular Reductive Amination/Asymmetric Hydrogenation: Facile Access to Sterically Tunable Chiral Vicinal Diamines and N-Heterocyclic Carbenes

A highly enantioselective iridium- or ruthenium-catalyzed intermolecular reductive amination/asymmetric hydrogenation relay with 2-quinoline aldehydes and aromatic amines has been developed. A broad range of sterically tunable chiral N,N′-diaryl vicinal diamines were obtained in high yields (up to 95 %) with excellent enantioselectivity (up to >99 % ee). The resulting chiral diamines could be readily transformed into sterically hindered chiral N-heterocyclic carbene (NHC) precursors, which are otherwise difficult to access. The usefulness of this synthetic approach was further demonstrated by the successful application of one of the chiral vicinal diamines and chiral NHC ligands in a transition-metal-catalyzed asymmetric Suzuki–Miyaura cross-coupling reaction and asymmetric ring-opening cross-metathesis, respectively.