410086-27-0

Basic information

• Product Name: 1(2H)-Isoquinolinone,7-fluoro-(9CI)
• Synonyms: 1(2H)-Isoquinolinone,7-fluoro-(9CI);7-Fluoro-1-isoquinolone;7-Fluoro-2H-isoquinolin-1-one;7-Fluoro-1-hydroxyisoquinoline;7-Fluoroisoquinolin-1-ol, 7-Fluoro-1-hydroxy-2-azanaphthalene;7-fluoroisoquinolin-1-ol;7-Fluoroisoquinolin-1(2H)-one;EOS-61223
• CAS NO: 410086-27-0
• Molecular Formula: C₉H₆FNO
• Molecular Weight: 163.1484432
• Product Categories: HALIDE
• Mol File: 410086-27-0.mol
• Article Data: 12

Chemical Properties

• Melting Point: 231-233 °C(Solv: ethyl acetate (141-78-6))
• Boiling Point: 376.6±42.0 °C(Predicted)
• Appearance: /
• Density: 1.291
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 12.08±0.20(Predicted)
• CAS DataBase Reference: 1(2H)-Isoquinolinone,7-fluoro-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1(2H)-Isoquinolinone,7-fluoro-(9CI)(410086-27-0)
• EPA Substance Registry System: 1(2H)-Isoquinolinone,7-fluoro-(9CI)(410086-27-0)

Safety Data

• Hazardous Substances Data: 410086-27-0(Hazardous Substances Data)

Usage

General Description

1(2H)-Isoquinolinone,7-fluoro-(9CI) is a chemical compound with the molecular formula C9H6FNO. Also known as 7-Fluoroisoquinolin-1(2H)-one, it is a derivative of isoquinolinone with a fluorine atom at the 7 position. 1(2H)-Isoquinolinone,7-fluoro-(9CI) is a heterocyclic organic compound and a member of the isoquinoline family, which is known for its diverse biological activities. While limited information is available on the specific uses and properties of 1(2H)-Isoquinolinone,7-fluoro-(9CI), it is likely to possess similar characteristics and potential applications, such as in pharmaceuticals, agrochemicals, and materials science, as other isoquinolinones. However, further research and testing would be necessary to uncover its full range of properties and potential uses.

Upstream product

• 459-32-5 4-fluorocinnamic acid 
• 57381-39-2 2-bromo-5-fluorobenzonitrile 
• 1009-00-3 7-fluoroisoquinoline 2-oxide 
• 1075-12-3 7-fluoroisoquinoline 
• 73261-94-6 N-<(3-fluorophenyl)methylene>-2,2-dimethoxyethanamine 
• 456-48-4 3-Fluorobenzaldehyde 
• 1711-07-5 3-fluorobenzoyl chloride 
• 455-38-9 3-fluorobenzoic acid 
• 108-05-4 vinyl acetate 
• 1427180-46-8 3-fluoro-N-(pivaloyloxy)benzamide 
• 459-32-5 (E)-4-fluorocinnamic acid 
• 928032-28-4 (E)-3-(4-fluorophenyl) acryloyl azide 

Downstream Products

• 630422-89-8 1-chloro-7-fluoroisoquinoline 
• 444898-89-9 C₃₅H₂₆FNO₈ 

Relevant articles and documents

Synthesis of Isoquinolones by Sequential Suzuki Coupling of 2-Halobenzonitriles with Vinyl Boronate Followed by Cyclization

A novel, facile, and expeditious two-step synthesis of 3,4-unsubstituted isoquinolin-1(2H)-ones from a Suzuki cross-coupling between 2-halobenzonitriles and commercially available vinyl boronates followed by platinum-catalyzed nitrile hydrolysis and cyclization is described.

ACTIVATORS OF AUTOPHAGIC FLUX AND PHOSPHOLIPASE D AND CLEARANCE OF PROTEIN AGGREGATES INCLUDING TAU AND TREATMENT OF PROTEINOPATHIES

The present application discloses compounds which are activators of autophagic flux and pharmaceutical compositions comprising said activators. It further discloses use of said compounds and pharmaceutical compositions in the treatment of neurodegenerative diseases, particularly proteinopathies and tauopathies such as Alzheimer's disease. It further discloses methods of enhancing autophagic flux.

HEPATITIS C VIRUS INHIBITORS

Hepatitis C virus inhibitors having the general formula (I) are disclosed. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.