41019-36-7

Basic information

• Product Name: 5-(2-NITRO-PHENYL)FURAN-2-CARBOXYLIC ACID METHYL ESTER
• Synonyms: 5-(2-NITRO-PHENYL)FURAN-2-CARBOXYLIC ACID METHYL ESTER;RARECHEM AL BF 0773;5-(2-nitrophenyl)-2-Furancarboxylic acid methyl ester
• CAS NO: 41019-36-7
• Molecular Formula: C₁₂H₉NO₅
• Molecular Weight: 247.2
• Mol File: 41019-36-7.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-(2-NITRO-PHENYL)FURAN-2-CARBOXYLIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2-NITRO-PHENYL)FURAN-2-CARBOXYLIC ACID METHYL ESTER(41019-36-7)
• EPA Substance Registry System: 5-(2-NITRO-PHENYL)FURAN-2-CARBOXYLIC ACID METHYL ESTER(41019-36-7)

Safety Data

• Hazardous Substances Data: 41019-36-7(Hazardous Substances Data)

Upstream product

• 2527-99-3 methyl 5-bromo-2-furoate 
• 5570-19-4 2-nitrophenylboronic acid 
• 67-56-1 methanol 
• 29048-34-8 5-(2-nitrophenyl)-2-furoic acid 

Downstream Products

• 29048-34-8 5-(2-nitrophenyl)-2-furoic acid 
• 54023-14-2 5-(2-aminophenyl)furan-2-carboxylic acid methyl ester 

Relevant articles and documents

Discovery and development of novel salicylate synthase (MbtI) furanic inhibitors as antitubercular agents

We report on the virtual screening, synthesis, and biological evaluation of new furan derivatives targeting Mycobacterium tuberculosis salicylate synthase (MbtI). A receptor-based virtual screening procedure was applied to screen the Enamine database, identifying two compounds, I and III, endowed with a good enzyme inhibitory activity. Considering the most active compound I as starting point for the development of novel MbtI inhibitors, we obtained new derivatives based on the furan scaffold. Among the SAR performed on this class, compound 1a emerged as the most potent MbtI inhibitor reported to date (Ki = 5.3 μM). Moreover, compound 1a showed a promising antimycobacterial activity (MIC99 = 156 μM), which is conceivably related to mycobactin biosynthesis inhibition.

(5-Arylfuran-2-ylcarbonyl)guanidines as cardioprotectives through the inhibition of Na+/H+ exchanger isoform-1

A series of (5-arylfuran-2-ylcarbonyl)guanidines was synthesized and evaluated for the NHE-1 inhibitory activity and cardiprotective efficacy against ischemia-reperfusion injury. Starting with (5-phenylfuran-2-ylcarbonyl) guanidine 47 with a moderate inhibitory effect on NHE-1, the compounds with various substituents at the phenyl ring were investigated with the aim to optimize the potency. In this study, the 2,5-disubstituted compounds appeared to have better activities than the other analogues, and the 2-methoxy-5- chlorophenyl compound 85 was found as a potent inhibitor of NHE-1 (IC 50 = 0.081 μM). Furthermore, 85 showed a marked reduction of infarct size in the rat myocardial infarction model in vivo and significant improvement of cardiac contractile function in the isolated rat heart ischemia model in vitro.