4107-65-7

Basic information

• Product Name: 2,4-Dimethoxybenzonitrile
• Synonyms: 2,4-DIMETHOXYBENZONITRILE;Benzonitrile, 2,4-dimethoxy-;2,4-Dimethoxybenzonitrile,99%;2,4-Dimethoxybenzoni;2,4 methoxybenzonitrile
• CAS NO: 4107-65-7
• Molecular Formula: C₉H₉NO₂
• Molecular Weight: 163.17
• EINECS: 223-886-2
• Product Categories: Aromatic Nitriles;C8 to C9;Cyanides/Nitriles;Nitrogen Compounds
• Mol File: 4107-65-7.mol
• Article Data: 83

Chemical Properties

• Melting Point: 93-94 °C(lit.)
• Boiling Point: 290.25°C (rough estimate)
• Flash Point: 128.8 °C
• Appearance: White to slightly yellow/Crystalline Powder
• Density: 1.2021 (rough estimate)
• Vapor Pressure: 0.000758mmHg at 25°C
• Refractive Index: 1.5300 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• BRN: 1950512
• CAS DataBase Reference: 2,4-Dimethoxybenzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Dimethoxybenzonitrile(4107-65-7)
• EPA Substance Registry System: 2,4-Dimethoxybenzonitrile(4107-65-7)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36-36/37
• RIDADR: 3276
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 4107-65-7(Hazardous Substances Data)

Usage

Chemical Properties

white to slightly yellow crystalline powder

Uses

2,4-Dimethoxybenzonitrile was used in the preparation of 2,4-dimethoxybenzylamine.

InChI:InChI=1/C9H9NO2/c1-11-8-4-3-7(6-10)9(5-8)12-2/h3-5H,1-2H3

Upstream product

• 1984-21-0 1-isocyano-2,4-dimethoxybenzene 
• 151-50-8 potassium cyanide 
• 151-10-0 1,3-Dimethoxybenzene 
• 31874-34-7 2,4-dimethoxybenzaldoxime 
• 75-15-0 carbon disulfide 
• 7446-70-0 aluminium trichloride 
• 506-68-3 bromocyane 
• 31874-34-7 (E)-2,4-dimethoxybenzaldehyde oxime 
• 110-05-4 di-tert-butyl peroxide 
• 673-22-3 2-Hydroxy-4-methoxybenzaldehyde 
• 38064-90-3 2,4-dimethoxytoluene 
• 20469-63-0 1-iodo-2,4-dimethoxybenzene 
• 68-12-2 N,N-dimethyl-formamide 
• 17715-69-4 1-Bromo-2,4-dimethoxybenzene 

Downstream Products

• 680-31-9 N,N,N,N,N,N-hexamethylphosphoric triamide 
• 20781-20-8 2,4-Dimethoxybenzylamine 
• 156630-35-2 4-(2,4-dimethoxybenzoyl)-2H-spiro 
• 154325-05-0 4-(2,4-dimethoxybenzoyl)-2,2-dimethyl-2H-thiochromene 
• 2735-04-8 2,4-Dimethoxyaniline 
• 3555-84-8 2,4-dimethoxybenzophenone 
• 20781-23-1 bis(2,4-dimethoxybenzyl)amine 
• 35088-22-3 2-amino-N-(2,4-dimethoxybenzyl)acetamide 
• 20781-35-5 N-Trifluoracetyl-glycin-(2.4-dimethoxy-benzyl-amid) 
• 20781-38-8 N-(p-Methoxy-benzyloxycarbonyl)-glycin-(2,4-dimethoxy-benzylamid) 
• 21079-32-3 N-Benzyloxycarbonyl-L-methionin-(2,4-dimethoxy-benzyl-amid) 
• 20839-67-2 N-(p-Methoxy-benzyloxycarbonyl)-L-methionin-(2,4-dimethoxy-benzyl-amid) 
• 20839-74-1 p-Methoxy-benzyloxycarbonyl-glycyl-glycin-(2,4-dimethoxy-benzylamid) 
• 20781-37-7 N-Benzyloxycarbonyl-glycin- 

Relevant articles and documents

Envirocat EPZG(R), a new catalyst for the conversion of aldoximes into nitriles

The conversion of aldoximes into nitriles was carried out at 100°C in the absence of a solvent using Envirocat EPZG(R) as a new solid supported catalyst.

Electrochemical Oxidative C?H Cyanation of Quinoxalin-2(1H)-ones with TMSCN

Both quinoxalin-2(1H)-ones and nitriles are valuable organic compounds, and it is an interesting task to introduce cyano into quinoxalin-2(1H)-ones. Herein a regioselective C?H cyanation of quinoxalin-2(1H)-ones was developed with a nucleophilic cyano source TMSCN under electrochemical oxidative conditions. This process allowed the synthesis of C3 cyanated quinoxalin-2(1H)-ones in moderate to excellent yields in the absence of transition-metal catalysts and organic hydroperoxides.

Method for converting aromatic aldehyde into aromatic nitrile by using sulfur powder promoted inorganic ammonium as nitrogen source (by machine translation)

The invention discloses a method for converting aromatic aldehyde into aromatic nitrile. The method is conversion of high yield of aromatic aldehyde one-pot reaction of sulfur powder promoted inorganic ammonium as a nitrogen source into aromatic nitrile. The method has the advantages of no need of metal participation, no need of strong oxide, compatibility of reaction to air, easiness in amplification to a gram scale and the like, and overcomes the problems of harsh reaction conditions, complex operation, low functional group compatibility and the like in the prior art. (by machine translation)

Organophotoredox assisted cyanation of bromoarenes: via silyl-radical-mediated bromine abstraction

The insertion of a nitrile (-CN) group into arenes through the direct functionalization of the C(sp2)-Br bond is a challenging reaction. Herein, we report an organophotoredox method for the cyanation of aryl bromides using the organic photoredox catalyst 4CzIPN and tosyl cyanide (TsCN) as the nitrile source. A photogenerated silyl radical, via a single electron transfer (SET) mechanism, was employed to abstract bromine from aryl bromide to provide an aryl radical, which was concomitantly intercepted by TsCN to afford the aromatic nitrile. A range of substrates containing electron-donating and -withdrawing groups was demonstrated to undergo cyanation at room temperature in good yields.