41150-46-3

Basic information

• Product Name: 2-HYDROXYMETHYL-BENZOIC ACID METHYL ESTER
• Synonyms: METHYL 2-(HYDROXYMETHYL)BENZOATE;2-HYDROXYMETHYL-BENZOIC ACID METHYL ESTER;RARECHEM AL BD 0437;Benzoicacid, 2-(hydroxyMethyl)-, Methyl ester
• CAS NO: 41150-46-3
• Molecular Formula: C₉H₁₀O₃
• Molecular Weight: 166.17
• Product Categories: pharmacetical
• Mol File: 41150-46-3.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 302.251 °C at 760 mmHg
• Flash Point: 133.143 °C
• Appearance: /
• Density: 1.177 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 14.08±0.10(Predicted)
• CAS DataBase Reference: 2-HYDROXYMETHYL-BENZOIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-HYDROXYMETHYL-BENZOIC ACID METHYL ESTER(41150-46-3)
• EPA Substance Registry System: 2-HYDROXYMETHYL-BENZOIC ACID METHYL ESTER(41150-46-3)

Safety Data

• Hazardous Substances Data: 41150-46-3(Hazardous Substances Data)

Usage

General Description

2-Hydroxymethyl-benzoic Acid Methyl Ester is a chemical compound typically used in organic synthesis and as a precursor in the synthesis of other chemical compounds. It is a type of ester, a category of organic compounds produced by the reaction of an oxoacid with a hydroxy compound. The molecular formula for this chemical is C9H10O3, indicating nine carbon atoms, ten hydrogen atoms, and three oxygen atoms in each molecule. The presence of the benzoic acid group in its structure denotes potential properties like acidity and reactivity. As with many chemicals, handling this compound should be carried out while observing proper safety measures as it may pose potential risks.

Upstream product

• 67-56-1 methanol 
• 87-41-2 2-benzofuran-1(3H)-one 
• 4397-55-1 phthalic monoacid monomethyl ester chloride 
• 74-88-4 methyl iodide 
• 2417-73-4 methyl 2-bromomethylbenzoate 
• 4376-18-5 Monomethyl phthalate 
• 487-97-8 1-ethoxy-1,3-dihydroisobenzofuran-1-ylium borofluorate 

Downstream Products

• 4122-56-9 methyl o-formylbenzoate 
• 14736-49-3 2-(2-(methoxycarbonyl)phenyl)acetic acid 
• 87-41-2 2-benzofuran-1(3H)-one 
• 51707-35-8 2-hydroxymethyl-benzoic acid hydrazide 

Relevant articles and documents

Electrochemical direct carboxylation of benzyl alcohols having an electron-withdrawing group on the phenyl ring: One-step formation of phenylacetic acids from benzyl alcohols under mild conditions

Electrochemical direct carboxylation of benzyl alcohols having an electron-withdrawing group on the phenyl ring was successfully carried out by constant current electrolysis using an undivided cell equipped with a platinum plate cathode and a magnesium rod anode in DMF in the presence of carbon dioxide. Reductive cleavage of the C-O bond followed by fixation of carbon dioxide efficiently took place at the benzylic position without any additive to give the corresponding phenylacetic acids in good yields in one step under neutral and mild conditions.

Practical and chemoselective reduction of acyl chloride to alcohol by borohydride in aqueous dichloromethane

A simple methodology for the reduction of acid chlorides to their corresponding alcohols has been developed. Various carboxylic acids were converted to alcohols in excellent yields using NaBH4-K2CO3 in a mixed solvent system of dichloromethane and water (1:1) in the presence of a phase-transfer catalyst at low temperature. The importance of the work is its simplicity, selectivity, excellent yield, and very short reaction time. This new reduction condition has proved to be an excellent chemoselective method for a range of acid chlorides in the presence of various functional groups.

A simple method for the reduction of carboxylic acids to aldehydes or alcohols using H2 and Pd/C

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