41198-08-7 Usage
Description
Profenofos is a pale yellow liquid, bp 100 ?C/1.80 Pa, vp
0.124 mPa (25 ?C). Solubility in water is 28 mg/L (25 ?C).
It is miscible with most organic solvents. Log Kow = 4.44.
It is relatively stable in neutral and mild acid media but
hydrolyzed in alkaline media; DT50 values (20 ?C) at pH 5,
7, and 9 are 93 d, 14.6 d, and 5.7 h, respectively.
Chemical Properties
Profenofos is a pale yellow liquid. Profenofos is relatively
stable under neutral and slightly acidic conditions and unstable
under alkaline conditions.Profenofos has a garlic-like odor.
Profenofos has limited solubility in water
(28 mg/L at 25°C) but is completely soluble
in organic solvents (ethanol, acetone, toluene,
n-octanol and n-hexane) at 25°C.
Uses
Different sources of media describe the Uses of 41198-08-7 differently. You can refer to the following data:
1. A broad-spectrum organophosphorous pesticide that is used widely in cotton fields for insect control.
2. Insecticide; acaricide.
3. Profenofos is used to control insects (particularly caterpillars and
Lepidoptera eggs) and mites on cotton, maize, sugar beet, soyabean,
potatoes, vegetables, tobacco and a number of other crops
General Description
Pale yellow liquid with garlic-like odor. Corrosive. Used as an insecticide.
Air & Water Reactions
Hydrolyzed under alkaline conditions.
Reactivity Profile
Organophosphates are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.
Agricultural Uses
Profenofos: Profenofos is A U.S. EPA restricted Use Pesticide (RUP) used solely on cotton to control a number of pests including tobacco budworm, cotton aphid and bollworm, armyworm, fleahopper and whiteflies. It is not registered for residential use. Not approved for use in EU countries. Registered for use in the U.S.
Trade name
CGA-15324?; CURACRON?; POLYCRON?; SELECRON?
Carcinogenicity
In a 2 year carcinogenicity study
mice were given diets containing 0, 1, 30, or 100 ppm profenofos
(equivalent to 0, 0.15, 4.5, or 15 mg/kg/day) for 85
weeks (males) or 97 weeks (females) . No treatment related clinical signs were observed. No treatment-related
gross or microscopic lesions, tumors, or biologically significant
differences in body weight or food consumption were
observed between controls and profenofos-treated animals.
Plasma and erythrocyte cholinesterase inhibition occurred at
dose levels of 4.5 and 15 mg/kg/day.
In another carcinogenicity study, rats were fed diets containing
0, 0.3, 10, or 100 ppm profenofos (equivalent to 0,
0.015, 0.5, or 5 mg/kg/day) for 2 years, and there was no
increase in tumor incidence in any treated group compared to
the control group .
Environmental Fate
Plant. Dislodgable residues of profenofos on cotton leaf 0, 24, 48, 72 and 96 hours
after application (1.1 kg/ha) were 3.5, 1.1, 0.74, 0.51 and 0.35 μg/m2, respectively (Buck
et al., 1980)Photolytic. When profenofos in an aqueous buffer solution (pH 7.0) was exposed to
filtered UV light (λ >290 nm) for 24 hours at 25 and 50°C, 29 and 61% respectively
decomposed to 4-bromo-2-chlorophenol and 4-bromo-2-chlorophenyl ethyl hydrogen
phChemical/Physical. Emits toxic fumes of bromine, chlorine phosphorus and sulfur
oxides when heated to decomposition (Sax and Lewis, 1987).
Metabolic pathway
The metabolic transformations of profenofos in plants and animals are
similar and occur via hydrolysis to 4-bromo-2-chlorophenol which is then
conjugated.
Metabolism
Profenofos
orally administered to rats is rapidly excreted, mainly in
the urine. The principal degradation route is hydrolysis to
4-bromo-2-chlorophenol followed by conjugation. DT50 in
soil is about 1 week.
Toxicity evaluation
The acute
oral LD50 for rats is 358 mg/kg. Inhalation LC50 (4 h) for
rats is about 3 mg/L air. NOEL (2 yr) for rats is 0.3 mg/kg diet (0.015 mg/kg/d). ADI is 0.01 mg/kg b.w.
Degradation
Profenofos is stable under neutral and slightly acid conditions but it is
hydrolysed in alkaline solution. The DT50 values at pH 5, 7 and 9 (20°C)
were 93 days, 14.6 days and 5.7 hours, respectively (PM).
Check Digit Verification of cas no
The CAS Registry Mumber 41198-08-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,1,1,9 and 8 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 41198-08:
(7*4)+(6*1)+(5*1)+(4*9)+(3*8)+(2*0)+(1*8)=107
107 % 10 = 7
So 41198-08-7 is a valid CAS Registry Number.
InChI:InChI=1/C11H15BrClO3PS/c1-3-7-18-17(14,15-4-2)16-11-6-5-9(12)8-10(11)13/h5-6,8H,3-4,7H2,1-2H3
41198-08-7Relevant articles and documents
Macrocyclic plant acaricides
-
, (2008/06/13)
Compounds of the formula I STR1 in which either R is methyl and there is a double bond in the 9,10-position, or in which R is hydrogen and there is a single bond in the 9,10-position, are highly active against Acarina which damage plants.
