412293-87-9

Basic information

• Product Name: 1-Boc-4-butylpiperazine
• Synonyms: 1-BOC-4-BUTYLPIPERAZINE;tert-butyl 4-butylpiperazine-1-carboxylate;4-BUTYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
• CAS NO: 412293-87-9
• Molecular Formula: C13H26N2O2
• Molecular Weight: 242.36
• Mol File: 412293-87-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 308.304 °C at 760 mmHg
• Flash Point: 140.258 °C
• Appearance: /
• Density: 0.984 g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.472
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-Boc-4-butylpiperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Boc-4-butylpiperazine(412293-87-9)
• EPA Substance Registry System: 1-Boc-4-butylpiperazine(412293-87-9)

Safety Data

• Hazardous Substances Data: 412293-87-9(Hazardous Substances Data)

Usage

General Description

1-Boc-4-butylpiperazine, also known as N-Butyl-4-tert-butoxycarbonylpiperazine, is a chemical compound that belongs to the piperazine class of organic compounds. It is commonly used as a reagent in organic synthesis and pharmaceutical research, particularly in the development of new drugs and pharmaceuticals. 1-Boc-4-butylpiperazine is known for its ability to modify various organic molecules, and its unique structure and functional groups make it a versatile building block in the synthesis of complex organic compounds. Additionally, 1-Boc-4-butylpiperazine has potential applications in the field of medicinal chemistry, particularly in the development of drugs targeting the central nervous system and other therapeutic areas. Overall, 1-Boc-4-butylpiperazine is a valuable and versatile chemical that has various applications in organic synthesis and pharmaceutical research.

InChI:InChI=1/C13H26N2O2/c1-5-6-7-14-8-10-15(11-9-14)12(16)17-13(2,3)4/h5-11H2,1-4H3

Upstream product

• 123-72-8 butyraldehyde 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 
• 109-65-9 1-bromo-butane 

Downstream Products

• 174358-28-2 PD 161654 

Relevant articles and documents

Triton B-mediated mild, convenient, and efficient method for the selective alkylation of cyclic secondary amines and thiols

Alkylation of cyclic secondary amines, thiols, and pyridazinones has been demonstrated with alkyl halides using Triton B as base and reaction medium.

Structure-activity relationships of the quinolone antibacterials against mycobacteria: Effect of structural changes at N-1 and C-7

The re-emergence of tuberculosis infections which are resistant to conventional drug therapy has demonstrated the need for alternative chemotherapy against Mycobacterium tuberculosis. As part of a study to optimize the quinolone antibacterials against M. tuberculosis, we have prepared a series of N-1- and C-7-substituted quinolones to examine specific structure-activity relationships between modifications of the quinolone at these two positions and activity against mycobacteria. The compounds, synthesized by literature procedures, were evaluated for activity against Mycobacterium fortuitum and Mycobacterium smegmatis as well as Gram-negative and Gram-positive bacteria. The activity of the compounds against M. fortuitum was used as a barometer of M. tuberculosis activity. The results demonstrate that (i) the activity against mycobacteria was related more to antibacterial activity than to changes in the lipophilicity of the compounds, (ii) the antimycobacterial activity imparted by the N-1 substituent was in the order tert-butyl ≥ cyclopropyl > 2,4-difluorophenyl > ethyl ? cyclobutyl > isopropyl, and (iii) substitution with either piperazine or pyrrolidine heterocycles at C-7 afforded similar activity against mycobacteria.