4144-64-3

Basic information

• Product Name: BENZOTRIAZOL-1-YL-ACETIC ACID
• Synonyms: RARECHEM AL BO 1318;TIMTEC-BB SBB006998;BENZOTRIAZOL-1-YL-ACETIC ACID;ART-CHEM-BB B003330;AKOS B003330;AKOS BBS-00000214;1H-1,2,3-BENZOTRIAZOL-1-YLACETIC ACID;(1H-BENZOTRIAZOL-1-YL)ACETIC ACID
• CAS NO: 4144-64-3
• Molecular Formula: C₈H₇N₃O₂
• Molecular Weight: 177.16
• Mol File: 4144-64-3.mol
• Article Data: 23

Chemical Properties

• Boiling Point: 427.2 °C at 760 mmHg
• Flash Point: 212.2 °C
• Appearance: /
• Density: 1.48 g/cm³
• Vapor Pressure: 4.65E-08mmHg at 25°C
• Refractive Index: 1.701
• Storage Temp.: 2-8°C
• Solubility: DMSO (Slightly), Methanol (Very Slightly)
• CAS DataBase Reference: BENZOTRIAZOL-1-YL-ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: BENZOTRIAZOL-1-YL-ACETIC ACID(4144-64-3)
• EPA Substance Registry System: BENZOTRIAZOL-1-YL-ACETIC ACID(4144-64-3)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 4144-64-3(Hazardous Substances Data)

Usage

Uses

Benzotriazol-1-ylacetic Acid is used as a reagent in the synthesis of benzotriazole imidazoline compounds which are used as metal corrosion inhibitors. Benzotriazol-1-ylacetic Acid is also a reagent in the synthesis of N-(benzo[1,2,3]triazol-1-yl)-N-((benzyl)acetamido)phenyl carboxamides which are used as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors.

InChI:InChI=1/C8H7N3O2/c12-8(13)5-11-7-4-2-1-3-6(7)9-10-11/h1-4H,5H2,(H,12,13)

Upstream product

• 13351-73-0 1-methyl-1H-benzo[d][1,2,3]triazole 
• 124-38-9 carbon dioxide 
• 1137060-81-1 benzotriazol-1-ylacetic acid tert-butyl ester 
• 95-14-7 1,2,3-Benzotriazole 
• 3926-62-3 sodium monochloroacetic acid 
• 79-11-8 chloroacetic acid 
• 79-08-3 bromoacetic acid 
• 105-39-5 chloroacetic acid ethyl ester 
• 111198-08-4 1-(cyanomethyl)benzotriazole 
• 69218-46-8 ethyl (1H-benzotriazol-1-yl)acetate 

Downstream Products

• 158502-20-6 1-benzotriazoleacetyl chloride 
• 482-89-3 1H,1H'-2,2'-Biindolylidene-3,3'-dione 
• 302897-96-7 (2-acetyl)phenol 2-(1-benzotriazolyl)acetate 
• 605681-58-1 2-(1H-1,2,3-benzotriazol-1-yl)-N-methoxy-N-methylacetamide 
• 1374967-53-9 (3R)-7-((1H-benzo[d][1,2,3]triazol-1-yl)methyl)-5-oxo-8-(pyridin-3-yl)-3,5-dihydro-2H-thiazolo[3,2-a]pyridine-3-carboxylate lithium salt 
• 1374967-39-1 (3R)-7-((1H-benzo[d][1,2,3]triazol-1-yl)methyl)-8-cyclopropyl-5-oxo-3,5-dihydro-2H-thiazolo[3,2-a]pyridine-3-carboxylate lithium salt 
• 1374967-41-5 (3R)-7-((1H-benzo[d][1,2,3]triazol-1-yl)methyl)-8-isopropyl-5-oxo-3,5-dihydro-2H-thiazolo[3,2-a]pyridine-3-carboxylate lithium salt 

Relevant articles and documents

A novel 1,2,3-benzotriazolium based ionic liquid monomer for preparation of MMT/poly ionic liquid (PIL) pH-sensitive positive charge nanocomposites

Abstract : In this work, a new ionic liquid (IL) with two acidic and vinylic functional groups based on 1,2,3-benzotriazolium cation was synthesized. This IL monomer was intercalated into the montmorillonite (MMT) layers by the ion exchange reaction and subsequently copolymerized with the IL monomer and methacrylic acid in order to obtain positive charge pH-sensitive nanocomposites. The structure of the IL monomer was characterized by FT-IR and 1H -NMR spectroscopy, and the structure of the nanocomposites was studied and confirmed by the FT-IR, XRD, TGA, SEM, and EDX data. These pH-sensitive nanocarriers were used to load and in vitro release of the anticancer drug, methotrexate (MTX) in pH?= 4 and pH?= 7.4. The results showed that the release is pH dependent and more effective in acidic pH; therefore, these nanocarriers have potential to be used for cancer therapy. Graphical abstract : SYNOPSIS Synthesis and characterization of a new dual functional ionic liquid monomer and use of it to prepare positive charge pH-sensitive nanocomposites for anti-cancer drug delivery application. Results showed that use of only this monomer in the structure of nanocomposite is more effective to the delivery of negatively charged drugs. [Figure not available: see fulltext.].

Visible-Light-Promoted Site-Selective N1-Alkylation of Benzotriazoles with α-Diazoacetates

A visible-light-promoted highly site-selective N1-alkylation of benzotriazoles with diazo compounds has been achieved under mild and metal-free conditions. Using cheap, readily available p-benzoquinone (PBQ) as a catalyst, a wide range of benzotriazoles and diazo compounds are reacted, providing N1-alkylated benzotriazoles in moderate to excellent yields with excellent N1-selectivities. Preliminary mechanistic studies suggest that a radical process accounts for the exclusive site-selectivity of this transformation.

Fundamental structure-activity relationships associated with a new structural class of respiratory syncytial virus inhibitor

Structure-activity relationships surrounding the dialkylamino side chain of a series of benzotriazole-derived inhibitors of respiratory syncytial virus fusion based on the screening lead 1a were examined. The results indicate that the topology of the side chain is important but the terminus element offers considerable latitude to modulate physical properties.

NITROGEN SUBSTITUTED AROMATIC TRIAZOLES AS CORROSION CONTROL AGENTS

Compositions and methods for inhibiting corrosion of metallic surfaces in contact with an aqueous medium such as copper, copper alloy, and steel surfaces of an open recirculating cooling water system. In certain embodiments, an aromatic triazole having an anionic substituent bonded to a nitrogen atom of the triazole (ANST) is used as the corrosion inhibitor. In other embodiments, the corrosion inhibitor is a reaction product of an aromatic triazole and an aldehyde (ATA).