41489-76-3

Basic information

• Product Name: Methyl 5-formyl-2-hydroxybenzoate
• Synonyms: 5-FORMYL-2-HYDROXYBENZOIC ACID METHYL ESTER;Methyl 5-formyl-2-hydroxybenzoate;5-formylsalicylic acid methyl ester;2-Hydroxy-5-formylbenzoic acid methyl ester;Methyl 5-Formylsalicylate;5-Formylsalicylic Acid Methyl Ester Methyl 5-Formyl-2-hydroxybenzoate 5-Formyl-2-hydroxybenzoic Acid Methyl Ester;Isophthalaldehydic acid, 6-hydroxy-, methyl ester
• CAS NO: 41489-76-3
• Molecular Formula: C₉H₈O₄
• Molecular Weight: 180.16
• EINECS: 1308068-626-2
• Product Categories: Acids and Derivatives;Carbonyl Compounds;API intermediates
• Mol File: 41489-76-3.mol
• Article Data: 22

Chemical Properties

• Melting Point: 79.0 to 83.0 °C
• Boiling Point: 294.5 °C at 760 mmHg
• Flash Point: 118.2 °C
• Appearance: /
• Density: 1.31g/cm³
• Vapor Pressure: 0.000918mmHg at 25°C
• Refractive Index: 1.594
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 7.57±0.18(Predicted)
• CAS DataBase Reference: Methyl 5-formyl-2-hydroxybenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 5-formyl-2-hydroxybenzoate(41489-76-3)
• EPA Substance Registry System: Methyl 5-formyl-2-hydroxybenzoate(41489-76-3)

Safety Data

• Hazardous Substances Data: 41489-76-3(Hazardous Substances Data)

Usage

General Description

Methyl 5-formyl-2-hydroxybenzoate is a chemical compound that belongs to the class of benzoic acid derivatives. It is also known by its systematic name, methyl 2-hydroxy-5-formylbenzoate. Methyl 5-formyl-2-hydroxybenzoate is used in various industries, including pharmaceuticals, cosmetics, and food additives. It has been identified as a potential anti-inflammatory and antioxidant agent, making it valuable for medicinal and cosmetic applications. Its chemical structure consists of a methyl group, a formyl group, and a hydroxyl group attached to a benzene ring, giving it unique chemical properties and potential biological activities. Overall, methyl 5-formyl-2-hydroxybenzoate is a versatile compound with potential applications in various fields.

InChI:InChI=1/C9H8O4/c1-13-9(12)7-4-6(5-10)2-3-8(7)11/h2-5,11H,1H3

Upstream product

• 105-45-3 acetoacetic acid methyl ester 
• 2009-81-6 2-dimethylaminomethylene-1,3-bis(dimethylimonio)propane diperchlorate 
• 100-97-0 hexamethylenetetramine 
• 119-36-8 methyl salicylate 
• 67-56-1 methanol 
• 69-72-7 salicylic acid 
• 74-88-4 methyl iodide 
• 616-76-2 2-hydroxy-5-formylbenzoic acid 

Downstream Products

• 873214-85-8 2-dodecyloxy-5-formyl-benzoic acid methyl ester 
• 183430-63-9 methyl-2-hydroxy-5-hydroxymethylbenzoate 
• 7437-20-9 2-hydroxy-5-(hydroxymethyl)benzoic acid 
• 1071618-98-8 (Z)-5-[2-(3,4,5-trimethoxyphenyl)ethenyl]-2-hydroxybenzoic acid methyl ester 
• 1197202-49-5 3-(methoxycarbonyl)-4-methoxymethoxybenzaldehyde 
• 1203454-75-4 1-(3-methoxycarbonyl-4-hydroxybenzylidene)-2-(4-hydroxybenzylidene)hydrazine 
• 1203454-83-4 C₁₈H₁₆N₂O₆ 
• 5466-23-9 bis(4-hydroxybenzylidene)hydrazine 

Relevant articles and documents

PYRROLOBENZODIAZEPINE DIMER PRECURSOR AND LIGAND-LINKER CONJUGATE COMPOUND THEREOF

The present invention relates to a pyrrolobenzodiazepine dimer prodrug and a ligand-linker conjugate compound thereof, a composition containing these, and therapeutic use thereof particularly as an anticancer drug. The stability of the compounds themselves and the stability thereof in plasma are excellent and the compounds are advantageous in terms of manifestation of toxicity, and thus the compounds are industrially useful in that it is possible to target proliferative diseases such as cancer, to perform a specific treatment, to maximize the drug efficacy, and to minimize the occurrence of side effects.

Thiosemicarbazone Dynamic Combinatorial Chemistry: Equilibrator-Induced Dynamic State, Formation of Complex Libraries, and a Supramolecular On/Off Switch

Dynamic combinatorial libraries that equilibrate under thermodynamic control and can be trapped kinetically when desired are key to creating complex systems that can mimic dynamic biological systems, such as the biochemical system of life. A much-sought-after feature is the ability to turn off the dynamic exchange of the system, in order to investigate a transient state away from thermodynamic equilibrium, and then turn on the dynamic exchange again. We describe here the first use of thiosemicarbazone exchange to form dynamic combinatorial libraries. The libraries were found to require a nucleophilic catalyst, or equilibrator, in order to reach thermodynamic equilibrium. This equilibrator approach adds a supramolecular level of control over the dynamic system and allows the dynamic exchange to be turned off by addition of 18-crown-6, which binds the equilibrator in a nonnucleophilic complex. The dynamic exchange can be restarted by addition of potassium ions that competitively bind 18-crown-6, thus liberating the equilibrator. The highly complex thiosemicarbazone-based macrocyclic libraries contain both [2]catenanes and sequence isomers, which can be distinguished by HPLC-MS/MS.

1-PHENYL-2-PYRIDINYL ALKYL ALCOHOL DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS

Compounds of formula (I) described herein are inhibitors of the phosphodiesterase 4 (PDE4) enzyme and are useful for the prevention and/or treatment of an allergic disease state or a disease of the respiratory tract characterized by airway obstruction.