41492-05-1Relevant articles and documents
Synthesis method of p-bromo-linear alkylbenzene
-
Paragraph 0035; 0049, (2017/08/25)
The invention belongs to the technical field of fine chemical industry, and in particular discloses a clean and efficient synthetic process technology of p-bromo-linear alkylbenzene. Paradibromobenzene and linear chain 1-haloalkane are added into an organic solvent, and reaction is conducted under the action of a catalyst ferric acetylacetonate and an activating agent consisting of zinc halide and magnesium powder to obtain the p-bromo-linear alkylbenzene. A paradibromobenzene single coupling technology is adopted, so production of ortho/meta isomers which are difficult to separate is avoided from the source; a Grignard reagent, which is instable to water and air, or an expensive boric acid reagent intermediate is not used, so that the production cost is reduced; a one-pot reaction technology is adopted, so that operation is simplified and good industrial application value is achieved.
Two flavors of PEPPSI-IPr: Activation and diffusion control in a single NHC-ligated Pd catalyst?
Larrosa, Igor,Somoza, Clara,Banquy, Alexandre,Goldup, Stephen M.
supporting information; experimental part, p. 146 - 149 (2011/03/20)
Abnormal reactivity has been observed in Negishi, Suzuki-Miyaura, and Kumada-Tamao-Corriu cross-couplings in which PEPPSI-IPr (where PEPPSI stands for pyridine enhanced precatalyst preparation, stabilization, and initiation and IPr refers to the NHC ligand) is employed, implicating the presence of two distinct Pd0 species in the catalytic cycle. Polybrominated arenes and organometallic reagents react selectively to give the product of exhaustive polysubstitution regardless of the initial reaction stoichiometry. Competition experiments suggest that, after an initial activation controlled oxidative addition, reductive elimination produces an ultrareactive Pd0 species which consumes all remaining C-Br bonds in the molecule under diffusion control.
Palladium-catalyzed cross-coupling alkylation of arenediazonium o-benzenedisulfonimides
Barbero, Margherita,Cadamuro, Silvano,Dughera, Stefano
, p. 474 - 478 (2008/09/21)
Arenediazonium o-benzenedisulfonimides were reacted with tetramethyltin, tetrabutyltin or trialkylboranes. The reactions, carried out in the presence of palladium(II) derivatives as precatalysts, gave the methylation and alkylation products with good over