41661-56-7Relevant articles and documents
Very Strong and Selective Complexation of Small Metal Ions by a Highly Preorganised Open-chain Bispidine-based Ligand
Hosken, Gladys D.,Hancock, Robert D.
, p. 1363 - 1364 (1994)
Synthesis of 3,7-bis(2-pyridylmethyl)-3,7-diazabicyclononane DPB, with very rigid nitrogen-bridge reinforcement gives an adamantane-like structure once a metal ion is coordinated to DPB, and shows how remarkable stability enhancement and selectivity for metal ions on the basis of size can be achieved in non-macrocyclic ligands.
Development of a manufacturing process for 1-(1-pyridin-2-yl methyl-piperidin-4-yl)-1H-indole: A key intermediate for protein kinase C inhibitor LY317615
Boini, Sathish,Moder, Kenneth P.,Vaid, Radhe K.,Kopach, Micheal,Kobierski
, p. 1205 - 1211 (2012/12/23)
This contribution describes process development leading to the production of 1-(1-pyridin-2-yl methyl-piperidin-4-yl)-1H-indole (11). The title compound 11 was produced via a Leimgruber-Batcho indole synthesis using key intermediates 2-(2,2-dimethoxyethyl
Green chemistry approach to the synthesis of N-substituted piperidones
Faul, Margaret M.,Kobierski, Michael E.,Kopach, Michael E.
, p. 5739 - 5741 (2007/10/03)
An efficient green chemistry approach to the synthesis of N-substituted piperidones and piperidines was developed and applied to the synthesis of 1-(2-pyridinylmethyl)-piperidin-4-one, 1, a key starting material for the synthesis of LY317615, an antiangio