41764-73-2

Basic information

• Product Name: N-(4-(HYDRAZINECARBONYL)PHENYL)-ACETAMIDE
• Synonyms: ART-CHEM-BB B003408;AKOS BBB/112;AKOS B003408;TIMTEC-BB SBB000312;N-(4-(HYDRAZINECARBONYL)PHENYL)-ACETAMIDE;N-(4-HYDRAZINOCARBONYL-PHENYL)-ACETAMIDE;4-Acetamidobenzoic acid, hydrazide;4AcNPhCON2
• CAS NO: 41764-73-2
• Molecular Formula: C₉H₁₁N₃O₂
• Molecular Weight: 193.2
• Mol File: 41764-73-2.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• Density: 1.287 g/cm³
• Refractive Index: 1.625
• CAS DataBase Reference: N-(4-(HYDRAZINECARBONYL)PHENYL)-ACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-(HYDRAZINECARBONYL)PHENYL)-ACETAMIDE(41764-73-2)
• EPA Substance Registry System: N-(4-(HYDRAZINECARBONYL)PHENYL)-ACETAMIDE(41764-73-2)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 41764-73-2(Hazardous Substances Data)

Usage

General Description

N-(4-(hydrazinecarbonyl)phenyl)-acetamide is a chemical compound with the molecular formula C9H10N4O2. It is a hydrazine derivative and an acetamide. N-(4-(HYDRAZINECARBONYL)PHENYL)-ACETAMIDE is an intermediate in the synthesis of pharmaceuticals and is also used in research and development processes. It is important to handle this chemical with care, as it can be hazardous if not used properly. Its properties and reactivity make it useful in various chemical reactions, especially in the production of pharmaceutical compounds.

InChI:InChI=1/C9H11N3O2/c1-6(13)11-8-4-2-7(3-5-8)9(14)12-10/h2-5H,10H2,1H3,(H,11,13)(H,12,14)

Upstream product

• 556-08-1 p-(acetylamino)benzoic acid 
• 150-13-0 4-amino-benzoic acid 
• 17012-22-5 methyl 4-acetamidobenzoate 
• 619-50-1 4-nitrobenzoic acid methyl ester 
• 62-23-7 4-nitro-benzoic acid 
• 619-45-4 4-methoxycarbonyl aniline 
• 121-90-4 m-nitrobenzoic acid chloride 
• 94-09-7 p-aminoethylbenzoate 
• 5338-44-3 ethyl p-acetamidobenzoate 

Downstream Products

• 174622-83-4 1-[4-(acetylamino)benzoyl]-4-ethyl-thiosemicarbazide 
• 23269-70-7 N-(4-(5-mercapto-1,3,4-oxadiazol-2-yl)phenyl)acetamide 
• 203268-83-1 5-(4-aminophenyl)-1,3,4-oxadiazole-2-thiol 
• 1457674-17-7 N-(4-(1,3,4-oxadiazole-2-yl)phenyl)acetamide 
• 1158910-84-9 N-{4-[3-methyl-4-oxo-4H-naphthalen-(1E)-ylidenehydrazinocarbonyl]phenyl}acetamide 
• 103046-55-5 4-(4-ethoxy-benzylidenamino)-benzoic acid-(4-ethoxy-benzylidenehydrazide) 

Relevant articles and documents

AMINO ALCOHOL DERIVATIVE, PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF

The present invention belongs to the field of medicine, and specifically discloses an amino alcohol derivative represented by Formula I, a pharmaceutically acceptable salt, solvate, polymorph or prodrug thereof. In addition, the present invention also discloses a pharmaceutical composition comprising the above substances, and a use of the substance in the preparation of a medicament for the prevention and treatment of an immune inflammatory disease, or a disease or condition associated with immunological competence such as multiple sclerosis, ALS, CIDP, systemic lupus erythematosus, rheumatoid arthritis, ulcerative colitis, psoriasis, polymyositis, etc.

Synthesis, chemical characterization and antimicrobial activity of new acylhydrazones derived from carbohydrates

A new series of glycosylated acylhydrazones was synthesized and all the chemical structures were confirmed by High Resolution Mass Spectrometry (HRMS), 1H and 13C Nuclear Magnetic Resonance (1H-NMR; 13C-NMR) and Fourier Transform Infrared (FTIR) spectroscopy methods. The mass accuracy between the calculated and found values observed in HRMS analyses were near or lower than 5 ppm, which are acceptable for proposing a molecular formula using this technique. All of the synthesized compounds were screened for their antibacterial, antifungal and antiviral activities. Five compounds (12, 13, 14, 16 and 19) exerted a modest antifungal activity against the strains evaluated. Derivative 14 showed fungicidal activity against Candida glabrata at 173.8 μM and saccharide unit contributed to the increase of the antifungal potential against this strain. New chemical manipulation of derivative 14 can make it possible to obtain new potentially antimicrobial agents.

Design, synthesis, and evaluation of simple phenol amides as ERRγ agonists

Herein we report the design and synthesis of a series of simple phenol amide ERRγ agonists based on a hydrazone lead molecule. Our structure activity relationship studies in this series revealed the phenol portion of the molecule to be required for activity. Attempts to replace the hydrazone with more suitable chemotypes led to a simple amide as a viable alternative. Differential hydrogen-deuterium exchange experiments were used to help understand the structural basis for binding to ERRγ and aid in the development of more potent ligands.