4177-16-6

Basic information

• Product Name: 2-VINYLPYRAZINE
• Synonyms: VINYLPYRAZINE;2-VINYLPYRAZINE;ethenylpyrazine;Pyrazine, ethenyl-;Pyrazine, vinyl-;2-Vinylpyrazine,98%;Vinylpyrazine,98%;2-Vinylpyrazine, GC 98%
• CAS NO: 4177-16-6
• Molecular Formula: C₆H₆N₂
• Molecular Weight: 106.13
• EINECS: 224-045-2
• Product Categories: pharmacetical;Pyrazines, Pyrimidines & Pyridazines;Mono- & Polyalkylpyrazines;Pyrazines;Pyrazines, Pyrimidines & Pyridazines
• Mol File: 4177-16-6.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 75-77°C 30mm
• Flash Point: 60°C
• Appearance: straw to dark brown liquid
• Density: 1.046
• Vapor Pressure: 3.32mmHg at 25°C
• Refractive Index: 1.555-1.557
• Storage Temp.: Freezer
• PKA: 0.56±0.10(Predicted)
• Water Solubility: Slightly soluble in methanol, water.
• BRN: 105566
• CAS DataBase Reference: 2-VINYLPYRAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-VINYLPYRAZINE(4177-16-6)
• EPA Substance Registry System: 2-VINYLPYRAZINE(4177-16-6)

Safety Data

• Hazard Codes: Xn
• Statements: 10-41-37/38-22
• Safety Statements: 16-39-26
• RIDADR: 1993
• WGK Germany: 3
• HazardClass: 3
• PackingGroup: III
• Hazardous Substances Data: 4177-16-6(Hazardous Substances Data)

Usage

Chemical Properties

straw to dark brown liquid

Uses

It is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals.

InChI:InChI=1/C6H6N2/c1-2-6-5-7-3-4-8-6/h2-5H,1H2

Upstream product

• 50-99-7 D-glucose 
• 59-51-8 DL-methionine 
• 153800-11-4 2-ethynylpyrazine 
• 291763-66-1 2-((trimethylsilyl)ethynyl)pyrazine 
• 14508-49-7 2-chloropyrazin 
• 109-07-9 (RS)-2-methylpiperazine 
• 66580-25-4 dimethyl-(2-pyrazin-2-ylethyl)-amine 
• 6705-31-3 2-(2-hydroxyethyl)-pyrazine 
• 109-08-0 2-Methylpyrazine 

Downstream Products

• 861965-57-3 2-(1-benzylpyrrolidin-3-yl)pyrazine 
• 91391-83-2 2-phenylethyl-pyrazine 
• 109315-35-7 8-Fluoro-4-(4-fluoro-phenyl)-2-(2-pyrazin-2-yl-ethyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole 

Relevant articles and documents

Comparison of pyrazines formation in methionine/glucose and corresponding Amadori rearrangement product model

The generation of pyrazines in a binary methionine/glucose (Met/Glc) mixture and corresponding methionine/glucose-derived Amadori rearrangement product (MG-ARP) was studied. Quantitative analyses of pyrazines and methional revealed that MG-ARP generated more methional compared to Met/Glc, whereas lower content and fewer species of pyrazines were observed in the MG-ARP model. Comparing the availability of α-dicarbonyl compounds generated from the Met/Glc model, methylglyoxal (MGO) was a considerably effective α-dicarbonyl compound for the formation of pyrazines during MG-ARP degradation, but glyoxal (GO) produced from MG-ARP did not effectively participate in the corresponding formation of pyrazines due to the asynchrony on the formation of GO and recovered Met. Diacetyl (DA) content was not high enough to form corresponding pyrazines in the MG-ARP model. The insufficient interaction of precursors and rapid drops in pH limited the formation of pyrazines during MG-ARP degradation. Increasing reaction temperature could reduce the negative inhibitory effect by promoting the content of precursors.

One-pot Suzuki-Heck relay to prepare industrially valuable intermediates using the Pd-Cy?Phine catalyst system

A rare example of a one-pot, palladium-catalyzed Suzuki-Heck sequence has been developed with applicability to APIs and organoelectronic materials. High throughput screening was used to expedite development and survey strategies. Interchangeability of the coupling partners and the avoidance of intermediate isolation gives operational flexibility, which can be used to improve process efficiency and suppress by-product formation.

Pyridoarylphenyl oxazolidinone antibacterials, and related compositions and methods

Pyridoarylphenyl oxazolidinone compounds of the formula: in which the substituents have the meaning indicated in the description. These compounds are useful as antibacterial agents.