417717-04-5 Usage
Description
Lenvatinib Impurity d, also known as O-Demethyl Lenvatinib, is a metabolite of Lenvatinib (L329400). It is an orally active inhibitor of multiple receptor tyrosine kinases, including VEGF, FGF, and SCF receptors. Lenvatinib Impurity d plays a significant role in the pharmaceutical industry due to its potential applications in various therapeutic areas.
Uses
Used in Pharmaceutical Industry:
Lenvatinib Impurity d is used as an active pharmaceutical ingredient (API) for the development of drugs targeting multiple receptor tyrosine kinases. Its ability to inhibit these receptors makes it a promising candidate for the treatment of various diseases, including cancer.
Used in Anticancer Applications:
Lenvatinib Impurity d is employed as an anticancer agent, particularly in the treatment of solid tumors. It modulates several oncological signaling pathways, such as VEGF/VEGFR, FGF, and SCF receptors, exerting inhibitory effects on tumor growth and progression. Additionally, it may demonstrate synergistic anticancer effects when combined with conventional chemotherapeutic drugs, enhancing chemo-sensitivity and efficacy in resistant cases.
Used in Drug Development and Research:
Lenvatinib Impurity d serves as an essential compound in the development and research of novel drugs targeting receptor tyrosine kinases. It can be used in the synthesis of new drug candidates, as well as in the evaluation of their efficacy and safety in preclinical and clinical studies.
Used in Drug Delivery Systems:
To enhance the bioavailability and therapeutic outcomes of Lenvatinib Impurity d, various drug delivery systems can be employed. These systems, such as organic and metallic nanoparticles, can improve the delivery of the compound to the target site, potentially increasing its efficacy and reducing side effects.
Check Digit Verification of cas no
The CAS Registry Mumber 417717-04-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,1,7,7,1 and 7 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 417717-04:
(8*4)+(7*1)+(6*7)+(5*7)+(4*1)+(3*7)+(2*0)+(1*4)=145
145 % 10 = 5
So 417717-04-5 is a valid CAS Registry Number.
417717-04-5Relevant articles and documents
QUINOLYL-CONTAINING COMPOUND AND PHARMACEUTICAL COMPOSITION, AND USE THEREOF
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, (2022/02/19)
Provided is a quinolyl-containing compound as shown in general formula (I) or (II) or a pharmaceutically acceptable salt, a solvate, an active metabolite, a polymorph, an isotopic label, or an isomer thereof, and further provided are a pharmaceutical composition comprising the compound and use of the compound and the pharmaceutical composition. The provided compound has a dual molecule function, can serve as multi -target inhibitors of novel tyrosine kinase/histone deacetylase, can simultaneously achieve the effect of two inhibitors, has excellent biological activity and pharmacokinetic properties, and has the application potential particularly in the field of treatment of tumors.
