41790-33-4

Basic information

• Product Name: 2-(chloromethyl)-6-methoxynaphthalene
• Synonyms: 2-(chloromethyl)-6-methoxynaphthalene
• CAS NO: 41790-33-4
• Molecular Formula: C₁₂H₁₁ClO
• Molecular Weight: 206.66814
• Mol File: 41790-33-4.mol
• Article Data: 10

Chemical Properties

• Melting Point: 57-59 °C
• Boiling Point: 338.9±17.0 °C(Predicted)
• Appearance: /
• Density: 1.179±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2-(chloromethyl)-6-methoxynaphthalene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(chloromethyl)-6-methoxynaphthalene(41790-33-4)
• EPA Substance Registry System: 2-(chloromethyl)-6-methoxynaphthalene(41790-33-4)

Safety Data

• Hazardous Substances Data: 41790-33-4(Hazardous Substances Data)

Usage

General Description

2-(Chloromethyl)-6-methoxynaphthalene is a chemical compound consisting of a naphthalene core with a chloromethyl group and a methoxy group attached to it. It is commonly used as an intermediate in the synthesis of various organic compounds. This chemical is known for its aromatic and reactive properties, and it is often utilized in the production of pharmaceuticals, agrochemicals, and dyes. Additionally, it can be used as a building block in the creation of other complex chemical structures, making it a versatile and valuable compound in industrial and research settings. However, it is important to handle this chemical with care due to its potentially hazardous nature.

Upstream product

• 26386-94-7 2-methyl-6-methoxynaphthalene 
• 5043-02-7 6-methoxy-2-naphthoic acid methyl ester 
• 6297-10-5 ethyl 6-methoxy-2-naphthoate 
• 78112-30-8 6-methoxy-3,4-dihydronaphthalene-2-carboxylic acid 
• 42036-59-9 2-acetyl-6-chloronaphthalene 
• 5042-97-7 6-chloronaphthalene-2-carboxylic acid 
• 5042-96-6 methyl 6-chloro-2-naphtoate 
• 5111-65-9 2-Bromo-6-methoxynaphthalene 
• 3453-33-6 6-methoxynaphthalene-2-carbaldehyde 
• 2471-70-7 2-methoxy-6-naphthoic acid 
• 200875-37-2 2-bromo-6-isopropoxynaphthalene 
• 15231-91-1 6-bromo-naphthalen-2-ol 
• 60200-44-4 2-chloro-6-hydroxymethylnaphthalene 
• 60201-22-1 (6-methoxy-2-naphthyl)methanol 

Downstream Products

• 71056-96-7 2-(6-methoxynaphthalen-2-yl)acetonitrile 
• 60201-22-1 (6-methoxy-2-naphthyl)methanol 
• 23981-48-8 methyl 6-methoxy-2-naphthylacetate 
• 88285-49-8 1-benzhydryl-4-(6-methoxy-2-naphthyl)methylpiperazine 
• 88411-92-1 1-benzhydryl-4-(6-methoxy-2-naphthyl)methylpiperazine hydrochloride 

Relevant articles and documents

CATECHOL O-METHYLTRANSFERASE ACTIVITY INHIBITING COMPOUNDS

Compounds of formula (I), wherein R1 is as defined in the claims, exhibit COMT enzyme inhibiting activity and are thus useful as COMT inhibitors.

Synthesis and fluoride-induced chemiluminescent decomposition of bicyclic dioxetanes substituted with a 2-hydroxynaphthyl group

Five bicyclic dioxetanes bearing a 2-hydroxynaphthyl group, 1aA-1eA, were synthesized and their chemiluminescent decomposition was examined by the use of tetrabutylammonium fluoride (TBAF) as a base in DMSO. It was found that these dioxetanes hold completely the 'odd/even' relationship between the substitution pattern of hydroxy as a trigger on the naphthalene ring and their chemiluminescent efficiency, and that dioxetane 1aA exhibited chemiluminescence with the highest efficiency among those for the oxynaphthyl-substituted dioxetanes hitherto known. The significant change in chemiluminescent efficiency depending on the substitution pattern was clarified to be attributed to the marked change in singlet-chemiexcitation efficiency for charge-transfer-induced chemiluminescence (CTICL) of 1aA-1eA. In respect of the rate of CTICL-decomposition, 'odd/even' relationship was observed for 1aA-1dA.

Antihyperglycemic Activity of Novel Naphthalenyl 3H-1,2,3,5-Oxathiadiazole 2-Oxides

A series of naphthalenyl 3H-1,2,3,5-oxathiadiazole 2-oxides was prepared and tested for antihyperglycemic activity in the db/db mouse, a model for type 2 (non-insulin dependent) diabetes mellitus.Substitution at the 1-,5-, or 8-positions of the naphthalene ring with a halogen was found to be beneficial to antihyperglycemic activity. 4--3H-1,2,3,5-oxathiadiazole 2-oxide (45), one of the most potent compounds in this series, was selected for further pharmacological evaluation.