4180-62-5

Basic information

• Product Name: Z-GLY-SER-OH
• Synonyms: N-CARBOBENZOXYGLYCYL-L-SERINE;Z-GLYCYL-L-SERINE;Z-GLY-SER-OH;Cbz-Gly-L-Ser-OH;Z-Gly-L-Ser-OH;2-[[2-(benzyloxycarbonylamino)acetyl]amino]-3-hydroxy-propionic acid;3-hydroxy-2-[[2-(phenylmethoxycarbonylamino)acetyl]amino]propanoic acid;3-hydroxy-2-[2-(phenylmethoxycarbonylamino)ethanoylamino]propanoic acid
• CAS NO: 4180-62-5
• Molecular Formula: C₁₃H₁₆N₂O₆
• Molecular Weight: 296.28
• Mol File: 4180-62-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 641.7 °C at 760 mmHg
• Flash Point: 341.9 °C
• Appearance: /
• Density: 1.374 g/cm³
• Vapor Pressure: 2.4E-17mmHg at 25°C
• Refractive Index: 1.573
• Storage Temp.: -15°C
• CAS DataBase Reference: Z-GLY-SER-OH(CAS DataBase Reference)
• NIST Chemistry Reference: Z-GLY-SER-OH(4180-62-5)
• EPA Substance Registry System: Z-GLY-SER-OH(4180-62-5)

Safety Data

• Hazardous Substances Data: 4180-62-5(Hazardous Substances Data)

Usage

General Description

Z-GLY-SER-OH is a chemical compound composed of three amino acids: glycine (Gly), serine (Ser), and an acetyl group (Z). The Z-GLY-SER-OH molecule functions as a peptide, with the amino acids linked together through peptide bonds. Z-GLY-SER-OH is primarily used in biochemical and pharmaceutical research as a building block for larger peptides or proteins. Additionally, Z-GLY-SER-OH may have potential applications in drug development, as the specific sequence of amino acids in the molecule can influence its biological activity and targeting properties. Overall, Z-GLY-SER-OH plays a crucial role in the study and development of biologically active compounds and pharmaceuticals.

InChI:InChI=1/C13H16N2O6/c16-7-10(12(18)19)15-11(17)6-14-13(20)21-8-9-4-2-1-3-5-9/h1-5,10,16H,6-8H2,(H,14,20)(H,15,17)(H,18,19)

Upstream product

• 56-45-1 L-serin 
• 15050-24-5 N-(benzyloxycarbonyl)glycyl chloride 
• 56694-31-6 Benzyloxycarbonylamino-acetic acid 5,5-dimethyl-3-oxo-cyclohex-1-enyl ester 
• 64-17-5 ethanol 
• 108849-83-8 N-(N-benzyloxycarbonyl-glycyl)-L-serine methyl ester 
• 1138-80-3 N-(Benzyloxycarbonyl)glycine 
• 50622-95-2 benzyl (2-azido-2-oxoethyl)carbamate 

Downstream Products

• 19526-00-2 Z-Gly-Ser-hydrazide 

Relevant articles and documents

Scandium(III) triflate-promoted serine/threonine-selective peptide bond cleavage

The site-selective cleavage of peptide bonds is an important chemical modification that is useful not only for the structural determination of peptides, but also as an artificial modulator of peptide/protein function and properties. Here we report site-selective hydrolysis of peptide bonds at the Ser and Thr positions with a high conversion yield. This chemical cleavage relies on Sc(iii)-promoted N,O-acyl rearrangement and subsequent hydrolysis. The method is applicable to a broad scope of polypeptides with various functional groups, including a post-translationally modified peptide that is unsuitable for enzymatic hydrolysis. The system was further extended to site-selective cleavage of a native protein, Aβ1-42, which is closely related to the onset of Alzheimer's disease.