41927-50-8

Basic information

• Product Name: 1-Methyl-3-phenyl-2-pyrazoline-5-one
• Synonyms: 1-Methyl-3-phenyl-2-pyrazoline-5-one;2-Methyl-5-phenyl-2H-pyrazole-3(4H)-one;2-methyl-5-phenyl-4H-pyrazol-3-one;1-Methyl-3-phenyl-1H-pyrazol-5(4H)-one
• CAS NO: 41927-50-8
• Molecular Formula: C₁₀H₁₀N₂O
• Molecular Weight: 174.1992
• Mol File: 41927-50-8.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 305.17°C (rough estimate)
• Flash Point: 155.6 °C
• Appearance: /
• Density: 1.1455 (rough estimate)
• Vapor Pressure: 0.000134mmHg at 25°C
• Refractive Index: 1.6300 (estimate)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-Methyl-3-phenyl-2-pyrazoline-5-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Methyl-3-phenyl-2-pyrazoline-5-one(41927-50-8)
• EPA Substance Registry System: 1-Methyl-3-phenyl-2-pyrazoline-5-one(41927-50-8)

Safety Data

• Hazardous Substances Data: 41927-50-8(Hazardous Substances Data)

Usage

General Description

1-Methyl-3-phenyl-2-pyrazoline-5-one, also known as Edaravone, is a chemical compound with antioxidant and neuroprotective properties. It has been used in the treatment of acute ischemic stroke in Japan and in some other countries. Edaravone works by scavenging free radicals and protecting against oxidative stress, which can help to reduce cell damage and inflammation in the brain. This can result in improved neurological function and reduced disability in patients who have suffered a stroke. Overall, 1-Methyl-3-phenyl-2-pyrazoline-5-one has shown potential as a therapeutic agent for the treatment of stroke and other neurological disorders.

InChI:InChI=1/C10H10N2O/c1-12-10(13)7-9(11-12)8-5-3-2-4-6-8/h2-6H,7H2,1H3

Upstream product

• 22038-72-8 methyldiazene 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 7339-53-9 1-methylhydrazine dihydrochloride 
• 60-34-4 methylhydrazine 

Downstream Products

• 85094-09-3 1,4-Dimethyl-3-phenyl-1H-pyrano[2,3-c]pyrazol-6-one 
• 89522-24-7 1-methyl-3-phenyl-pyrazolo<3,4-b>quinoline 
• 883-38-5 5-chloro-1-methyl-3-phenyl-1H-pyrazole-4-carboxaldehyde 
• 62349-59-1 2-methyl-5-phenyl-pyrazole-3,4-dione 
• 1445896-27-4 6-amino-4-(4-methoxyphenyl)-1-methyl-3-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile 
• 1445896-22-9 6-amino-4-(4-fluorophenyl)-1-methyl-3-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile 

Relevant articles and documents

Asymmetric [3 + 3] Annulation of Copper-Allenylidenes with Pyrazolones: Synthesis of Chiral 1,4-Dihydropyrano[2,3- c]pyrazoles

The copper-catalyzed asymmetric [3 + 3] annulation of ethynyl benzoxazinanones with pyrazolones has been achieved, providing simple access to 1,4-dihydropyrano[2,3-c]pyrazole derivatives in moderate to excellent yields with excellent enantioselectivities (up to 99% ee). Compared with previous annulation reactions of copper-allenylidenes from ethynyl benzoxazinanones, the current reaction fused the three carbon atoms of the propargyl moiety into a heterocyclic framework.

ANTI-CANCER COMPOUNDS TARGET RAL GTPASES AND METHODS OF USING THE SAME

Methods of inhibiting the growth or metastasis of a cancer in a subject by inhibiting a Ral GTPase in the subject, and small molecule inhibitors of Ral GTPases useful in the methods of the invention. Pharmaceutical compositions containing the compounds of the invention, and methods of using the same.

P-Toluenesulphonic acid-promoted, I2-catalysed sulphenylation of pyrazolones with aryl sulphonyl hydrazides

Aryl pyrazolone thioethers were synthesized via the I2-catalysed cross-coupling of pyrazolones with aryl sulphonyl hydrazides in the presence of p-toluenesulphonic acid, which has been proposed to promote the reaction by facilitating the decomposition of sulphonyl hydrazides. This journal is