41965-95-1Relevant articles and documents
Practical preparation of 3-chloro-4-methoxybenzylamine hydrochloride
Endo, Masaki,Douglas, Jim
, p. 2609 - 2612 (2000)
The title compound was prepared in a practical manner by chlorinating 4- methoxybenzylamine with sulfuryl chloride in acetic acid in 79-82% yields with little side reaction.
COMPOSITION CONTAINING 3-CHLORO-4-METHOXYBENZYLAMINE HYDROCHLORIDE, AND METHOD FOR PRODUCING SAME
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Paragraph 0054, (2017/04/11)
There is provided a method for producing, at a high yield, a composition containing 3-chloro-4-methoxybenzylamine hydrochloride (CMBA-HCl) in which the purity of CMBA-HCl is high. This method comprises a chlorination step involving a chlorination reaction that generates CMBA-HCl from 4-methoxybenzylamine hydrochloride using hydrogen peroxide and hydrochloric acid. There is also provided a CMBA-HCl-containing composition which is produced by the aforementioned production method and in which the purity of CMBA-HCl is high.
Mono-chlorination of electron-rich arylalkyl- and heteroarylalkyl-amines and amino acids using sulfuryl chloride
Yu, Guixue,Mason, Helen J.,Galdi, Kim,Wu, Ximao,Cornelius, Lyndon,Zhao, Ning,Witkus, Michael,Ewing, William R.,Macor, John E.
, p. 403 - 407 (2007/10/03)
Sulfuryl chloride has been used to mono-chlorinate electron-rich arylalkyl- and heteroarylalkyl-amines and amino acids in a mild and efficient one-pot transformation with straightforward purification. Protection of the amines was not needed, and racemization of the chiral amino acids was minimal.