41995-30-6

Basic information

• Product Name: 3,5-dimethylpyridin-2-amine
• Synonyms: 3,5-dimethylpyridin-2-amine;2-Amino-3,5-dimethylpyridine;3,5-Dimethyl-2-pyridinamine;2-PyridinaMine, 3,5-diMethyl-;2-Amino-3,5-dimethylpyridine≥ 99% (HPLC)
• CAS NO: 41995-30-6
• Molecular Formula: C₇H₁₀N₂
• Molecular Weight: 122.1677
• EINECS: 255-613-8
• Mol File: 41995-30-6.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 239.9 °C at 760 mmHg
• Flash Point: 122 °C
• Appearance: /
• Density: 1.039g/cm³
• Vapor Pressure: 0.0392mmHg at 25°C
• Refractive Index: 1.564
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: 3,5-dimethylpyridin-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-dimethylpyridin-2-amine(41995-30-6)
• EPA Substance Registry System: 3,5-dimethylpyridin-2-amine(41995-30-6)

Safety Data

• Hazardous Substances Data: 41995-30-6(Hazardous Substances Data)

Usage

Chemical Properties

White or pale yellow solid

Uses

2-Amino-3,5-dimethylpyridine is used in the evaluation of?substituted 2-aminopyridines as inhibitors of nitric oxide synthases.

InChI:InChI=1/C7H10N2/c1-5-3-6(2)7(8)9-4-5/h3-4H,1-2H3,(H2,8,9)

Upstream product

• 3718-65-8 3,5-Dimethylpyridine N-oxide 
• 64-17-5 ethanol 
• 92992-85-3 2-bromine-3,5-dimethylpyridine 
• 591-22-0 3,5-Lutidine 

Downstream Products

• 117846-58-9 2,6-dibromo-3,5-dimethylpyridine 
• 1356000-38-8 {1-[4-(6,8-dimethyl-3-phenyl-imidazo[1,2-a]pyridin-2-yl)-phenyl]-cyclobutyl}-carbamic acid tert-butyl ester 

Relevant articles and documents

Catalyst-free synthesis of substituted pyridin-2-yl, quinolin-2-yl, and isoquinolin-1-yl carbamates from the corresponding hetaryl ureas and alcohols

A novel catalyst-free synthesis ofN-pyridin-2-yl,N-quinolin-2-yl, andN-isoquinolin-1-yl carbamates utilizes easily accessibleN-hetaryl ureas and alcohols. The proposed environmentally friendly technique is suitable for the good-to-high yielding synthesis of a wide range ofN-pyridin-2-yl orN-quinolin-2-yl substituted carbamates featuring electron-donating and electron-withdrawing groups in the azine rings and containing various primary, secondary, and even tertiary alkyl substituents at the oxygen atom (48-94%; 31 examples). The DFT calculation and experimental study showed that the reaction proceeds through the intermediate formation of hetaryl isocyanates. The method can be applied to obtainN-isoquinolin-1-yl carbamates, although in lower yields, and ethyl benzo[h]quinolin-2-yl carbamate has also been successfully synthesized (68%).

NOVEL COMPOUNDS

The present invention is directed to novel retinoid-related orphan receptor gamma (RORγ) modulators, processes for their preparation, pharmaceutical compositions containing these modulators, and their use in the treatment of inflammatory, metabolic and autoimmune diseases mediated by RORγ.

Substituted 2-aminopyridines as inhibitors of nitric oxide synthases.

A series of substituted 2-aminopyridines was prepared and evaluated as inhibitors of human nitric oxide synthases (NOS). 4,6-Disubstitution enhanced both potency and specificity for the inducible NOS with the most potent compound having an IC50 of 28 nM.