42019-78-3Relevant articles and documents
Metal-free C-C bond formation: Via coupling of nitrile aimines and boronic acids
Livingstone, Keith,Bertrand, Sophie,Mowat, Jenna,Jamieson, Craig
, p. 10412 - 10416 (2019)
The challenges of developing sustainable methods of carbon-carbon bond formation remains a topic of considerable importance in synthetic chemistry. Capitalizing on the highly reactive nature of the nitrile imine 1,3-dipole, we have developed a novel metal-free coupling of this species with aryl boronic acids. Photochemical generation of a nitrile imine intermediate and trapping with a palette of boronic acids enabled rapid and facile access to a broad library of more than 25 hydrazone derivatives in up to 92% yield, forming a carbon-carbon bond in a metal free fashion. This represents the first reported example of direct reaction between boronic acids and a 1,3-dipole.
Phenoxy aromatic acid compound with cyclopropyl and pharmaceutically acceptable salt thereof, and preparation method and application thereof
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Paragraph 0040-0043, (2021/07/17)
The invention provides a phenoxy aromatic acid compound with cyclopropyl, a preparation method of the phenoxy aromatic acid compound, pharmaceutically acceptable salt of the phenoxy aromatic acid compound and a preparation method of the pharmaceutically acceptable salt of the phenoxy aromatic acid compound, and further provides dosage forms of the phenoxy aromatic acid compound and the pharmaceutically acceptable salt of the phenoxy aromatic acid compound and application of the phenoxy aromatic acid compound and the pharmaceutically acceptable salt of the phenoxy aromatic acid compound in drugs for treating hyperlipidemia diseases. The compound provided by the invention has a relatively good blood fat reducing drug effect, so that the compound has a very good application prospect.
A sodium trifluoromethanesulfinate-mediated photocatalytic strategy for aerobic oxidation of alcohols
Zhu, Xianjin,Liu, Can,Liu, Yong,Yang, Haijun,Fu, Hua
supporting information, p. 12443 - 12446 (2020/10/30)
A sodium trifluoromethanesulfinate-mediated photocatalytic strategy for the aerobic oxidation of alcohols has been developed for the first time, and the photoredox aerobic oxidation of secondary and primary alcohols provided the corresponding ketones and carboxylic acids, respectively, in high to excellent yields.