42032-30-4Relevant articles and documents
Synthesis of N-alkylated derivatives of imidazole as antibacterial agents
Khabnadideh,Rezaei,Khalafi-Nezhad,Bahrinajafi,Mohamadi,Farrokhroz
, p. 2863 - 2865 (2007/10/03)
N-Alkylation of imidazole, 2-methylimidazole and 2-methyl-4-nitroimidazole have been carried out to achieve effective antibacterial agents. The products were then investigated for antibacterial activity against Escherichia coil, Staphylococcus aureus and Pseudomonas aeruginosa. Antibacterial effects of 1-alkylimidazole derivatives increase as the number of carbons in alkyl chain increases up to nine carbons. Also substitution of 2-methyl and 2-methyl-4-nitro groups on imidazole ring increases the antibacterial activity.