42047-33-6Relevant articles and documents
ADDITION-CYCLIZATION REACTIONS OF ETHYL ISOTHIOCYANATOACETATE WITH CARBOXYLIC ACIDS HYDRAZIDES
Veverka, Miroslav,Marchalin, Miroslav
, p. 113 - 119 (2007/10/02)
Ethyl (3-substituted 5-thioxo-1,2,4-triazolin-4-yl)acetates were prepared by addition-cyclization reaction of ethyl isothiocyanatoacetate with carboxylic acid hydrazides in the presence of sodium ethoxide.Thermal cyclization of the adduct in dimethylformamide afforded 1-acetamido-2-thiohydantoin.The effect of substituents on the cyclization course and the thione-thiol tautomerism are discussed.