4206-74-0

Basic information

• Product Name: N(4)-acetylsulfisoxazole
• Synonyms: N(4)-acetylsulfisoxazole;4'-(3,4-Dimethyl-5-isoxazolylaminosulfonyl)acetoanilide;5-[p-(Acetylamino)phenylsulfonylamino]-3,4-dimethylisoxazole;N-[4-(3,4-Dimethyl-5-isoxazolylaminosulfonyl)phenyl]acetamide
• CAS NO: 4206-74-0
• Molecular Formula: C₁₃H₁₅N₃O₄S
• Molecular Weight: 309.34
• Mol File: 4206-74-0.mol
• Article Data: 4

Chemical Properties

• Melting Point: 210 °C
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.3541 (rough estimate)
• Refractive Index: 1.6320 (estimate)
• PKA: 4.62±0.50(Predicted)
• Water Solubility: 7.579g/L(37 oC)
• CAS DataBase Reference: N(4)-acetylsulfisoxazole(CAS DataBase Reference)
• NIST Chemistry Reference: N(4)-acetylsulfisoxazole(4206-74-0)
• EPA Substance Registry System: N(4)-acetylsulfisoxazole(4206-74-0)

Safety Data

• Hazardous Substances Data: 4206-74-0(Hazardous Substances Data)

Upstream product

• 19947-75-2 5-amino-3,4-dimethylisoxazol 
• 121-60-8 p-acetylaminobenzenesulfonyl chloride 
• 4468-47-7 2-methyl-3-oxo-butyronitrile 
• 174079-07-3 (3,4-Dimethyl-isoxazol-5-yl)-carbamic acid tert-butyl ester 
• 127-69-5 sulfisoxazole 
• 108846-04-4 N-(N-acetyl-sulfanilyl)-2-methyl-acetoacetamidine 
• 108-24-7 acetic anhydride 

Downstream Products

• 324543-28-4 3-(2-chlorophenyl)-N-[4-(N-(3,4-dimethylisoxazol-5-yl)sulfamoyl)phenyl]acrylamide 
• 303018-63-5 N-[4-N-(3,4-dimethylisoxazol-5-ylsulfamoyl)phenyl]cinnamamide 
• 448931-96-2 N-[4-N-(3,4-dimethylisoxazol-5-ylsulfamoyl)phenyl]-3-phenylpropanamide 
• 547696-19-5 N-[4-(3,4-dimethylisoxazol-5-ylsulfamoyl)phenyl]-3-(4-methoxyphenyl)propionamide 
• 127-69-5 sulfisoxazole 

Relevant articles and documents

N-Acylated derivatives of sulfamethoxazole and sulfafurazole inhibit intracellular growth of chlamydia trachomatis

Antibacterial compounds with novel modes of action are needed for management of bacterial infections. Here we describe a high-content screen of 9,800 compounds identifying acylated sulfonamides as novel growth inhibitors of the sexually transmitted pathogen Chlamydia trachomatis. The effect was bactericidal and distinct from that of sulfonamide antibiotics, as para-Aminobenzoic acid did not reduce efficacy. Chemical inhibitors play an important role in Chlamydia research as probes of potential targets and as drug development starting points. Copyright

Discovery and synthesis of a potent sulfonamide ET(B) selective antagonist

The synthesis and structure-activity relationships of a series of sulfonamide endothelin antagonists are described. In the course of our modification studies, we discovered ET(B) selective antagonists. The most potent compound 15f displays IC50 values of 1.7 μM and 0.002 μM to ET(A) and ET(B) receptors, respectively. (C) 2000 Elsevier Science Ltd. All rights reserved.