42070-90-6

Basic information

• Product Name: (R)-1-(2-Methylphenyl)ethyl alcohol
• Synonyms: (R)-1-(2-Methylphenyl)ethyl alcohol;(R)-(+)-1-(2-Methylphenyl)-1-ethanol;(R)-1-(2-Methylphenyl)ethanol;(R)-1-(2-Tolyl)ethanol;(R)-1-(2-tolyphenyl)ethanol;(R)-1-(o-tolyl)ethan-1-ol
• CAS NO: 42070-90-6
• Molecular Formula: C₉H₁₂O
• Molecular Weight: 136.19098
• EINECS: -0
• Mol File: 42070-90-6.mol
• Article Data: 324

Chemical Properties

• Boiling Point: 216℃
• Flash Point: 104℃
• Appearance: /
• Density: 0.995
• CAS DataBase Reference: (R)-1-(2-Methylphenyl)ethyl alcohol(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-(2-Methylphenyl)ethyl alcohol(42070-90-6)
• EPA Substance Registry System: (R)-1-(2-Methylphenyl)ethyl alcohol(42070-90-6)

Safety Data

• Hazardous Substances Data: 42070-90-6(Hazardous Substances Data)

Usage

General Description

(R)-1-(2-Methylphenyl)ethyl alcohol is a chemical compound with the molecular formula C9H12O. It is also known as (R)-(+)-2-Methyl-1-phenylethanol or 2-Methyl-1-phenylethanol. This colorless liquid has a floral, fruity odor and is commonly used as a flavoring agent in the food and beverage industry. It is also used in the production of perfumes and other fragrances. Additionally, it has antimicrobial properties, making it useful in certain pharmaceutical and cosmetic applications. The compound is chiral, meaning it has two non-superimposable mirror image forms, and the (R) configuration is the specific stereochemistry of this compound.

Upstream product

• 7287-82-3 1-O-tolyl-ethanol 
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• 611-15-4 1-methyl-2-vinyl-benzene 
• 917-54-4 methyllithium 
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• 75-24-1 trimethylaluminum 
• 98-88-4 benzoyl chloride 
• 155095-22-0 2-acetyl-3-phenyl-l-menthopyrazole 
• 59790-53-3 trimethyl[1-(2-methylphenyl)vinyloxy]silane 

Downstream Products

• 7287-82-3 1-O-tolyl-ethanol 
• 1240815-57-9 (S)-(-)-1-(2-methylphenyl)ethyl N,N-diisopropylcarbamate 

Relevant articles and documents

First substoichiometric version of the catalytic enantioselective addition of an alkyllithium to an aldehyde

A substoichiometric enantioselective version of the extremely fast nucleophilic addition of Alk-Li to RCHO is made possible thanks to a thorough analysis of the aggregation phenomena involved in the reaction: calculated quantities of LiCl must be added to

Nickel-Catalyzed Enantioselective Hydroboration of Vinylarenes

The enantioselective hydroboration of vinylarenes catalyzed by a chiral, nonracemic nickel catalyst is presented as a facile method for generating chiral benzylic boronate esters. Various vinylarenes react with bis(pinacolato)diboron (B2pin2) in the presence of MeOH as a hydride source to form chiral boronate esters in up to 92% yield with up to 94% ee. The use of anhydrous Me4NF to activate B2pin2 is crucial for ensuring fast transmetalation to achieve high enantioselectivities.

Visible-Light-Driven Catalytic Deracemization of Secondary Alcohols

Deracemization of racemic chiral compounds is an attractive approach in asymmetric synthesis, but its development has been hindered by energetic and kinetic challenges. Here we describe a catalytic deracemization method for secondary benzylic alcohols which are important synthetic intermediates and end products for many industries. Driven by visible light only, this method is based on sequential photochemical dehydrogenation followed by enantioselective thermal hydrogenation. The combination of a heterogeneous dehydrogenation photocatalyst and a chiral molecular hydrogenation catalyst is essential to ensure two distinct pathways for the forward and reverse reactions. These reactions convert a large number of racemic aryl alkyl alcohols into their enantiomerically enriched forms in good yields and enantioselectivities.