4208-54-2

Basic information

• Product Name: 1-(Furan-2-yl)-2,2-dimethylpropan-1-one
• Synonyms: 1-(Furan-2-yl)-2,2-dimethylpropan-1-one
• CAS NO: 4208-54-2
• Molecular Formula: C₉H₁₂O₂
• Molecular Weight: 152.19038
• Mol File: 4208-54-2.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 63-65 °C(Press: 1 Torr)
• Appearance: /
• Density: 0.992±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 1-(Furan-2-yl)-2,2-dimethylpropan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(Furan-2-yl)-2,2-dimethylpropan-1-one(4208-54-2)
• EPA Substance Registry System: 1-(Furan-2-yl)-2,2-dimethylpropan-1-one(4208-54-2)

Safety Data

• Hazardous Substances Data: 4208-54-2(Hazardous Substances Data)

Usage

Physical state

Yellow liquid

Odor

Strong, sweet, and caramel-like

Usage

Flavor and fragrance industry as a flavoring agent

Additional uses

Production of resins, plastics, and pharmaceuticals

Production source

Furfuryl alcohol from biomass sources like corn cobs and sugarcane

Health concern

Potential human carcinogen

Safety precaution

Handle and use with caution

Upstream product

• 110-00-9 furan 
• 1538-75-6 2,2-dimethylpropanoic anhydride 
• 630-18-2 tert-butyl isocyanide 
• 4208-53-1 2-methyl-1-(2-furyl)-1-propanone 
• 74-88-4 methyl iodide 
• 3282-30-2 pivaloyl chloride 
• 4229-84-9 α-(1,1-dimethylethyl)furan-2-methanol 
• 98-01-1 furfural 
• 84379-72-6 1,3-dioxoisoindolin-2-yl 3,3-dimethylbutanoate 
• 118486-94-5 2-(tributylstannyl)furan 

Downstream Products

• 63688-34-6 2-tert-butyl-pyridin-3-ol 
• 76908-05-9 2-(2-furyl)-3,3-dimethyl-1-phenylbutan-2-ol 
• 76908-12-8 1-(3-benzyl-2-furyl)-2,2-dimethylpropan-1-one 
• 556811-68-8 1-(2'-furyl)-2,2-dimethylpropan-1-one tosyl hydrazone 
• 556811-67-7 1-(2'-furyl)-2,2-dimethylpropan-1-one benzenesulfonyl hydrazone 
• 556811-69-9 1-(2'-furyl)-2,2-dimethylpropan-1-one 4-methoxybenzenesulfonyl hydrazone 
• 188772-60-3 (Z)-1-(furan-2-yl)-2,2-dimethylpropan-1-one O-benzyloxime 
• 331852-24-5 (R)-1-(furan-2-yl)-2,2-dimethylpropanamine 

Relevant articles and documents

Chemoenzymatic approach to optically active 4-hydroxy-5-alkylcyclopent-2- en-1-one derivatives: An application of a combined circular dichroism spectroscopy and DFT calculations to assignment of absolute configuration

A series of representative optically active derivatives of 4-hydroxy-5-alkylcyclopent-2-en-1-one were prepared from the respective 2-furyl methyl carbinols via the Piancatelli rearrangement followed by the enzymatic kinetic resolution of racemates. Applicability of chiroptical methods (experimental and calculated electronic circular dichroism [ECD] and vibrational circular dichroism [VCD] spectra) to determine the absolute configuration of both stereogenic centers in 4-hydroxy-5-methylcyclopent-2-en-1-one was demonstrated. It was also demonstrated that the concurrent application of ECD and VCD spectroscopy can be used for the determination of the configuration of two stereogenic centers. Chirality 26:300-306, 2014. 2014 Wiley Periodicals, Inc.

N-Heterocyclic Carbene-Catalyzed Decarboxylative Alkylation of Aldehydes

We found that N-heterocyclic carbene catalysis promoted the unprecedented decarboxylative coupling of aryl aldehydes and tertiary or secondary alkyl carboxylic acid-derived redox-active esters to produce aryl alkyl ketones. The mild and transition-metal-free reaction conditions are attractive features of this method. The power of this protocol was demonstrated by the functionalization of pharmaceutical drugs and natural product. A reaction pathway involving single electron transfer from an enolate form of Breslow intermediate to a redox ester followed by recombination of the resultant radical pair to form a carbon-carbon bond is proposed.

RUTHENIUM COMPLEX AND PROCESS FOR PRODUCING TERT-ALKYL ALCOHOL THEREWITH

A tert-alkyl ketone, pinacolone was hydrogenated under pressurized hydrogen in the presence of a ruthenium complex (S)-1 and a base, and corresponding (S)-3,3,-dimethyl-2-butanol was thereby obtained in 100% yield and 97% ee.