42087-80-9

Basic information

• Product Name: METHYL 4-CHLORO-2-NITROBENZOATE
• Synonyms: 4-CHLORO-2-NITROBENZOIC ACID METHYL ESTER;METHYL 4-CHLORO-2-NITROBENZOATE;4-CHLORO-2-NITROBENZOIC ACID METHYL ESTER 97+%;2-Nitro-4-chlorobenzoic acid methyl ester
• CAS NO: 42087-80-9
• Molecular Formula: C₈H₆ClNO₄
• Molecular Weight: 215.59
• EINECS: 255-654-1
• Product Categories: blocks;Carboxes;NitroCompounds;Aromatic Esters;C8 to C9;Carbonyl Compounds;Esters
• Mol File: 42087-80-9.mol
• Article Data: 4

Chemical Properties

• Melting Point: 43-45 °C(lit.)
• Boiling Point: 285.6 °C at 760 mmHg
• Flash Point: >230 °F
• Appearance: /
• Density: 1.426 g/cm³
• Vapor Pressure: 0.00277mmHg at 25°C
• Refractive Index: 1.568
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: METHYL 4-CHLORO-2-NITROBENZOATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 4-CHLORO-2-NITROBENZOATE(42087-80-9)
• EPA Substance Registry System: METHYL 4-CHLORO-2-NITROBENZOATE(42087-80-9)

Safety Data

• Statements: R36/37/38:Irritating to eyes, respiratory system and skin.
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S36:Wear suitable prot
• WGK Germany: 3
• Hazardous Substances Data: 42087-80-9(Hazardous Substances Data)

Usage

General Description

Methyl 4-chloro-2-nitrobenzoate is a chemical compound with the molecular formula C8H6ClNO4. It is a yellow solid with a melting point of 92-94°C. METHYL 4-CHLORO-2-NITROBENZOATE is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also used in the production of dyes and pigments. Methyl 4-chloro-2-nitrobenzoate is known to be a skin and eye irritant, and proper safety precautions should be taken when handling this chemical.

InChI:InChI=1/C8H6ClNO4/c1-14-8(11)6-3-2-5(9)4-7(6)10(12)13/h2-4H,1H3

Upstream product

• 67-56-1 methanol 
• 6280-88-2 4-chloro-2-nitro-benzoic acid 
• 74-88-4 methyl iodide 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 5900-58-3 2-amino-4-chloro-benzoic acid methyl ester 
• 1139569-09-7 methyl 4-[6-(methyloxy)-3-pyridinyl]-2-nitrobenzoate 
• 1393803-55-8 6-chloro-3-hydroxybenzo[b]thiophene-2-carboxylic acid 
• 33851-22-8 6-chloro-3-hydroxybenzo[b]thiophene-2-carboxylic acid methyl ester 
• 857870-14-5 methyl 4-(((tert-butoxycarbonyl)amino)methyl)-2-nitrobenzoate 
• 773874-70-7 methyl 4-(dimethylamino)-2-nitrobenzoate 
• 99847-13-9 3-nitrobiphenyl-4-carboxylic acid 
• 887249-26-5 C₁₄H₁₀FNO₄ 
• 887244-16-8 methyl 3'-fluoro-3-nitro-4-biphenylcarboxylate 
• 855482-39-2 methyl 4'-[2-[benzyl(tert-butoxycarbonyl)amino]ethyl]-3-nitro-4-biphenylcarboxylate 
• 154890-41-2 8-chloro-5-(N-methylamino)-1-[4-[(2-methylbenzoyl)amino]benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine 
• 137977-41-4 8-chloro-1-[4-[(2-methylbenzoyl)amino]benzoyl]-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine 
• 137984-93-1 8-chloro-1-(4-nitrobenzoyl)-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine 
• 137984-96-4 1-(4-aminobenzoyl)-8-chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine 

Relevant articles and documents

NOVEL PIPERIDINE-2,6-DIONE DERIVATIVE AND USE THEREOF

The present disclosure relates to a novel piperidine-2,6-dione derivative and a use thereof and, more specifically, to a piperidine-2,6-dione derivative compound having a structure of a thalidomide analog. A compound of chemical formula 1 according to the present disclosure specifically binds with CRBN protein, and is involved in functions thereof. Therefore, the compound of the present disclosure can be favorably used in the prevention or treatment of leprosy, chronic graft versus host disease, an inflammatory disease, or cancer, which are caused by actions of CRBN protein.

Efficient synthesis and 5-LOX/COX-inhibitory activity of some 3-hydroxybenzo[b]thiophene-2-carboxylic acid derivatives

A series of 3-hydroxybenzo[b]thiophene-2-carboxylic acid derivatives has been prepared and subsequently evaluated with regards to the inhibition of 5-LOX/COX. Structure optimization furnished derivatives with promising in vitro activity as dual 5-LOX/COX inhibitors with submicromolar IC50 values for inhibition of 5-LOX and COX-1, respectively.