4211-87-4

Basic information

• Product Name: 5-(4-Chlorophenyl)-3-methylisoxazole
• Synonyms: 5-(4-Chlorophenyl)-3-methylisoxazole;ISOXAZOLE, 5-(4-CHLOROPHENYL)-3-METHYL-;3-methyl-5-(p-chlorophenyl)isoxazole
• CAS NO: 4211-87-4
• Molecular Formula: C₁₀H₈ClNO
• Molecular Weight: 193.632
• Mol File: 4211-87-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 309.875 °C at 760 mmHg
• Flash Point: 141.207 °C
• Appearance: /
• Density: 1.218 g/cm³
• CAS DataBase Reference: 5-(4-Chlorophenyl)-3-methylisoxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-Chlorophenyl)-3-methylisoxazole(4211-87-4)
• EPA Substance Registry System: 5-(4-Chlorophenyl)-3-methylisoxazole(4211-87-4)

Safety Data

• Hazardous Substances Data: 4211-87-4(Hazardous Substances Data)

Usage

General Description

5-(4-Chlorophenyl)-3-methylisoxazole, also known as 4-Chlorophenylisoxazol-5-ylmethanol, is a compound with the molecular formula C10H8ClNO. It is an isoxazole derivative with a chlorophenyl group and a methyl group attached to the isoxazole ring. This chemical has potential medicinal properties and is studied for its potential use in pharmaceuticals, particularly in the treatment of various medical conditions. It may also have applications in chemical research and synthesis. The compound's structure and properties make it a subject of interest for further investigation and potential development in the field of medicinal and pharmaceutical chemistry.

Upstream product

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Relevant articles and documents

Monohydrochloride Assisted Synthesis of Functionalized Isoxazoles and Pyrazoles from Allenic Ketones: First Synthesis of (Z)-2-Methyl-7H-benzo[b]pyrazolo[5,1-d][1,5]oxazocines

A facile hydrochloride promoted regioselective synthesis of isoxazoles and pyrazoles from 1,2-allenic ketones is reported. The reaction has been scaled up to gram scale. A direct 8-endo dig ring annulations towards the first synthesis of (Z)-2-methyl-7H-b

Clean and efficient synthesis of isoxazole derivatives in aqueous media

A series of 5-arylisoxazole derivatives were synthesized via the reaction of 3-(dimethyl-amino)-1-arylprop-2-en-1-ones with hydroxylamine hydrochloride in aqueous media without using any catalyst. This method has the advantages of easier work-up, mild rea

RING TRANSFORMATION REACTION OF 1,4,6-TRISUBSTITUTED 2(1H)-PYRIMIDINONES AND -THIONES WITH HYDROXYLAMINE

1,4,6-Trisubstituted 2(1H)-pyrimidinones (Ia-e) underwent ring transformation with hydroxylamine to afford 3,5-disubstituted isoxazoles (IIa-e) in high yields.On the other hand, 2(1H)-pyrimidinethiones (IIIa, b, f-k) underwent ring transformation to give mainly a new type of N-substituted 2-aminopyrimidine 1-oxides (IVa, b, f-k) as well as isoxazoles.The reaction of pyrimidinium salts (VII, VIII, and IX) with hydroxylamine is also discussed.Keywords: - ring tranformation reaction; hydroxylamine; nucleophilic reaction; 3,5-disubstituted isoxazoles; N-substituted 2-aminopyrimidine 1-oxides; pyrimidinium salts