42161-96-6

Basic information

• Product Name: 1-CYCLOPROPYL-1-(TRIMETHYLSILYLOXY)-ETHY LENE, 98
• Synonyms: 1-CYCLOPROPYL-1-(TRIMETHYLSILYLOXY)-ETHY LENE, 98;1-Cyclopropyl-1-(trimethylsilyloxy)ethylene;1-cyclopropyl-1-(trimethylsilyloxy)-ethylene;Silane, (1-cyclopropylethenyl)oxytrimethyl-;[(1-Cyclopropylethenyl)oxy]trimethylsilane;[1-(Trimethylsiloxy)vinyl]cyclopropane;1-Cyclopropyl-1-(trimethylsilyloxy)ethene;Trimethyl[(1-cyclopropylvinyl)oxy]silane
• CAS NO: 42161-96-6
• Molecular Formula: C₈H₁₆OSi
• Molecular Weight: 156.3
• Mol File: 42161-96-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 38-40 °C12 mm Hg(lit.)
• Flash Point: 84 °F
• Appearance: /
• Density: 0.845 g/mL at 25 °C(lit.)
• Vapor Pressure: 5.52mmHg at 25°C
• Refractive Index: n20/D 1.431(lit.)
• CAS DataBase Reference: 1-CYCLOPROPYL-1-(TRIMETHYLSILYLOXY)-ETHY LENE, 98(CAS DataBase Reference)
• NIST Chemistry Reference: 1-CYCLOPROPYL-1-(TRIMETHYLSILYLOXY)-ETHY LENE, 98(42161-96-6)
• EPA Substance Registry System: 1-CYCLOPROPYL-1-(TRIMETHYLSILYLOXY)-ETHY LENE, 98(42161-96-6)

Safety Data

• Hazard Codes: Xi
• Statements: 10-36/37/38
• Safety Statements: 16-26-36/37/39
• RIDADR: UN 1993 3/PG 3
• WGK Germany: 3
• HazardClass: 3.2
• PackingGroup: III
• Hazardous Substances Data: 42161-96-6(Hazardous Substances Data)

Usage

Cyclopropyl-containing compound

The presence of a cyclopropyl group (a three-carbon ring) makes this compound unique and valuable in organic synthesis.

Versatile building block

It is used in the synthesis of various pharmaceuticals, agrochemicals, and functional materials due to its ability to introduce the cyclopropyl group into organic molecules.

Reagent in organic reactions

1-Cyclopropyl-1-(trimethylsilyloxy)-ethylene, 98% is commonly used as a reagent to introduce the cyclopropyl group into other organic molecules.

Development of new synthetic methods

This compound is often employed in the research and development of new synthetic methods, contributing to advancements in organic chemistry.

Precursor to more complex organic compounds

It serves as a starting material for the synthesis of more complex organic compounds, further expanding its utility in various applications.

98% purity level

The high purity level of this compound (98%) indicates that it is of high quality and suitable for use in demanding applications in the fields of chemistry, pharmaceuticals, and material science.

InChI:InChI=1/C8H16OSi/c1-7(8-5-6-8)9-10(2,3)4/h8H,1,5-6H2,2-4H3

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 765-43-5 Cyclopropyl methyl ketone 
• 517-23-7 3-acetyl-2-oxo-4,5-dihydrofuran 
• 27607-77-8 trimethylsilyl trifluoromethanesulfonate 

Downstream Products

• 128672-59-3 1-cyclopropyl-3-methoxy-4-p-tolylthiopent-4-en-1-one 
• 128672-60-6 E-1-cyclopropyl-5-methoxy-4-p-tolylthiopent-4-en-1-one 
• 128672-61-7 Z-1-cyclopropyl-5-methoxy-4-p-tolylthiopent-4-en-1-one 
• 87910-06-3 2,2,-dimethyl-3-(4-chlorophenylthio)propyl cyclopropyl ketone 
• 125631-42-7 1-cyclopropyl-3-methoxy-6-p-tolylthiohexen-4-one-1 
• 103200-40-4 4-(4-Chloro-phenylsulfanyl)-1-cyclopropyl-3-methoxy-butan-1-one 
• 87910-11-0 2-<1-butoxy-2-(4-chlorophenylthio)>ethylcyclohexanone 
• 1066-40-6 Trimethylsilanol 
• 765-43-5 Cyclopropyl methyl ketone 
• 19980-43-9 1-(trimethylsilyloxy)cyclopentene 
• 110-62-3 pentanal 
• 175469-62-2 1-cyclopropyl-2-nitroethanone 
• 89867-79-8 (3-Cyclopropyl-2,2-diphenyl-oxetan-3-yloxy)-trimethyl-silane 
• 69267-75-0 2-bromo-1-cyclopropylethan-1-one 

Relevant articles and documents

One-pot enol silane formation-Mukaiyama aldol reactions: Crossed aldehyde-aldehyde coupling, thioester substrates, and reactions in ester solvents

Trimethylsilyl trifluoromethanesulfonate (TMSOTf) and a trialkylamine base promote both in situ enol silane/silyl ketene acetal formation and Mukaiyama aldol addition reactions between a variety of reaction partners in a single reaction flask. Isolation of the required enol silane or silyl ketene acetal is not necessary. For example, crossed aldol reactions between α-disubstituted aldehydes and non-enolizable aldehydes yield β-hydroxy aldehydes in good yield. In a related reaction, the common laboratory solvent ethyl acetate functions as both an enolate precursor and a green reaction solvent. When thioesters are employed as enolate precursors, high yields for additions to non-enolizable aldehydes are routinely observed.

Potent, selective, orally bioavailable inhibitors of tumor necrosis factor-α converting enzyme (TACE): Discovery of indole, benzofuran, imidazopyridine and pyrazolopyridine P1′ substituents

Potent and selective inhibitors of tumor necrosis factor-α converting enzyme (TACE) were discovered with several new heterocyclic P1′ groups in conjunction with cyclic β-amino hydroxamic acid scaffolds. Among them, the pyrazolopyridine provided the best o

IMPROVED PREPARATION OF BICYCLOPROPYLIDENE

A reproducible synthesis of the title compound 6 in 10 - 20 g quantities is reported.The use of a polymeric base such as (diethylaminomethyl)-polystyrene is exemplified in the transformation of a sensitive alcohol 4 into a labile chloride 5.