42164-56-7

Basic information

• Product Name: N,N-dibenzylpropane-1,2-diamine
• Synonyms: N,N-dibenzylpropane-1,2-diamine
• CAS NO: 42164-56-7
• Molecular Formula: C₁₇H₂₂N₂
• Molecular Weight: 254.37
• Mol File: 42164-56-7.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 382.3 °C at 760 mmHg
• Flash Point: 223 °C
• Appearance: /
• Density: 1.015 g/cm³
• PKA: 8.94±0.19(Predicted)
• CAS DataBase Reference: N,N-dibenzylpropane-1,2-diamine(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-dibenzylpropane-1,2-diamine(42164-56-7)
• EPA Substance Registry System: N,N-dibenzylpropane-1,2-diamine(42164-56-7)

Safety Data

• Hazardous Substances Data: 42164-56-7(Hazardous Substances Data)

Upstream product

• 42164-52-3 1,3-dibenzyl-4-methyl-2-phenyl-imidazolidine 
• 57-55-6 propylene glycol 
• 100-46-9 benzylamine 
• 133695-14-4 N,N'-dibenzylidenepropane-1,2-diamine 
• 100-52-7 benzaldehyde 
• 78-90-0 1,2-diaminopropan 
• 103-49-1 dibenzylamine 

Downstream Products

• 1354623-70-3 5,8-dibenzyl-7-methyl-5,8-diazaspiro[2.6]nonane 
• 75825-40-0 N,N'-dibenzyl-5-methyloctahydro-1,4,7-oxadiazonine 

Relevant articles and documents

METHOD FOR SYNTHESIZING AMINES

The invention relates to a process for preparing certain amines, wherein, in a first step, a corresponding amino alcohol is reacted with a suitable carbonyl compound and then, in a second step, the intermediate obtained in the first step is reacted with a suitable amine component to form the desired amine.

Iridium-catalyzed condensation of amines and vicinal diols to substituted piperazines

A straightforward procedure is described for the synthesis of piperazines from amines and 1,2-diols. The heterocyclization is catalyzed by [Cp*IrCl2]2 and sodium hydrogen carbonate and can be achieved with either toluene or water as solvent. The transformation does not require any stoichiometric additives and only produces water as the byproduct. The reaction can be performed between a 1,2-diamine and a 1,2-diol or by a double condensation between a primary alkylamine and a 1,2-diol. At least one substituent is required on the piperazine ring to achieve the cyclization in good yield. The mechanism is believed to involve dehydrogenation of the 1,2-diol to the α-hydroxy aldehyde, which condenses with the amine to form the α-hydroxy imine. The latter rearranges to the corresponding α-amino carbonyl compound, which then reacts with another amine followed by reduction of the resulting imine. Piperazines are prepared by [Cp*IrCl 2]2-catalyzed heterocyclization of 1,2-diols with either 1,2-diamines or primary alkylamines. The reaction is performed in toluene or water and requires no stoichiometric additive. The key step in the mechanism is believed to be the isomerization of an α-hydroxy imine to the corresponding α-amino carbonyl compound. Copyright

Synthesis and antitubercular activity of ferrocenyl diaminoalcohols and diamines

A total of 21 ferrocenyl and benzyl diaminoalcohols and diamines were synthesized and evaluated against Mycobacterium tuberculosis H37Rv. Interestingly, ferrocenyl diamines exhibit better activities than ferrocenyl diaminoalcohols.