42248-31-7

Basic information

• Product Name: 6-CHLORO-3-FORMYLCHROMONE
• Synonyms: TIMTEC-BB SBB003463;AKOS BBS-00001401;6-CHLORO-3-FORMYLCHROMONE;6-CHLORO-4-OXO-4 H-1-BENZOPYRAN-3-CARBOXALDEHYDE;6-CHLORO-4-OXO-4H-CHROMENE-3-CARBALDEHYDE;IFLAB-BB F2121-0036;6-CHLORO-3-FORMYLCHROMONE 97%;6-Chloro-3-formylchromone,97%
• CAS NO: 42248-31-7
• Molecular Formula: C₁₀H₅ClO₃
• Molecular Weight: 208.6
• Product Categories: Chromones
• Mol File: 42248-31-7.mol
• Article Data: 34

Chemical Properties

• Melting Point: 166-168 °C(lit.)
• Boiling Point: 351.896 °C at 760 mmHg
• Flash Point: 161.508 °C
• Appearance: yellow crystalline powder
• Density: 1.561 g/cm³
• Vapor Pressure: 3.98E-05mmHg at 25°C
• Refractive Index: 1.693
• CAS DataBase Reference: 6-CHLORO-3-FORMYLCHROMONE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-CHLORO-3-FORMYLCHROMONE(42248-31-7)
• EPA Substance Registry System: 6-CHLORO-3-FORMYLCHROMONE(42248-31-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 42248-31-7(Hazardous Substances Data)

Usage

Chemical Properties

yellow crystalline powder

InChI:InChI=1/C10H5ClO3/c11-7-1-2-9-8(3-7)10(13)6(4-12)5-14-9/h1-5H

Upstream product

• 876-27-7 4-chlorophenyl acetate 
• 106-48-9 4-chloro-phenol 
• 133662-20-1 1-(2-chlorophenyl)-2-hydroxyethanone 
• 68-12-2 N,N-dimethyl-formamide 
• 635-93-8 5-chlorosalicyclaldehyde 
• 1163120-28-2 6-chloro-3-(1-hydroxybut-3-en-1-yl)chromone 
• 1450-74-4 5-chloro-2-hydroxyacetophenone 
• 861296-77-7 3-(5-chloro-2-hydroxy-phenyl)-3-oxo-propionaldehyde 
• 79-37-8 oxalyl dichloride 

Downstream Products

• 101640-26-0 6-Chloro-2-ethoxy-3-[1-p-tolylamino-meth-(E)-ylidene]-chroman-4-one 
• 51085-92-8 6-chloro-4-oxo-4H-chromene-3-carboxylic acid 
• 192568-43-7 N-[Benzotriazol-1-yl-(6-chloro-4-oxo-4H-chromen-3-yl)-methyl]-benzamide 
• 50743-20-9 6-chloro-3-cyanochromone 
• 444794-36-9 3-(2-hydroxy-5-chlorobenzoyl)-5-methyl-7-(4-nitrophenyl)pyrazolo[3,4-b]pyridine 

Relevant articles and documents

Synthesis of Chromeno[2,3-d]pyrimidin-5-one Derivatives from 1,3,5-Triazinanes via Two Different Reaction Pathways

1,3,5-Triazinanes, as a kind of versatile building block, are applied in the synthesis of chromeno[2,3-d]pyrimidin-5-one derivatives via two different reaction modes, which perfectly exhibits the powerful function of 1,3,5-triazinane as a three-atom synth

Synthesis and biological evaluation of chromone-3-carboxamides

The aim of our study was to synthesize novel chromone-3-carboxamides and to conduct biological evaluations in search for lead compounds for the treatment of a range of debilitating disease states. Corresponding 2-hydroxyacetophenones were subjected to Vilsmeier-Haack formylation to give chromone-3-carbaldehydes, which were subsequently oxidised to give chromone-3-carboxylic acids. Treatment of the carboxylic acids with thionyl chloride resulted in the in situ formation of the corresponding acid chlorides, which were reacted with various amines in the presence of triethylamine to give the corresponding novel chromone-3-carboxamides in good yields. Selected chromone derivatives were then evaluated for their anti-inflammatory, anti-tryponosomal and cytotoxic properties.

NHC-Catalyzed Cascade Reaction between β-Methyl Enals and Dienones for Quick Construction of Complex Multicyclic Lactones

A NHC-promoted cascade reaction between β-methyl enal and dienone is developed for quick access to multicyclic lactone molecules bearing quaternary chiral carbon centers. Our study constitutes the first 1,6-addition of the acylazolium vinyl enolate γ-carbon via NHC catalysis and provides rapid access to complex lactone molecules that are otherwise difficult to prepare. The structurally sophisticated lactone products bearing up to four fused ring structures are afforded in up to quantitative yields with good to excellent enantioselectivities.